Influence of single nucleotide polymorphisms among cigarette smoking and non-smoking patients with coronary artery disease, urinary bladder cancer and lung cancer

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:DiVA.org:hj-53519" > Influence of single...

1 av 1
Föregående post
Nästa post
Till träfflistan

Influence of single nucleotide polymorphisms among cigarette smoking and non-smoking patients with coronary artery disease, urinary bladder cancer and lung cancer

Lewin, N. L. (författare): Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Karlsson, Jan-Erik (författare): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Ryhov Hosp, Sweden

Robinsson, D. (författare): Ryhov Hosp, Sweden

visa fler...

Fagerberg, M. (författare): Dept Urology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Kentsson, M. (författare): Dept of Internal Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Sayardoust, Shariel (författare): Dept Periodontology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Nilsson, Mats (författare): Linköpings universitet,Medicinska fakulteten,Institutionen för hälsa, medicin och vård,Academy of Health and Care, Region Jönköping, Jönköping, Sweden

Shamoun, L. (författare): Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Andersson, B. -Å. (författare): Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Löfgren, S. (författare): Dept Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

Rutqvist, L. E. (författare): Scientific Affairs Group, Swedish Match AB, Stockholm, Sweden

Lewin, F. (författare): Dept Oncology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Sweden

visa färre...

(creator_code:org_t)

2021-01-28
2021
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 16

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://journals.plo...; https://liu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Introduction Cigarette smoke is suggested to be a risk factor for coronary artery disease (CAD), urinary bladder cancer (UBCa) or lung cancer (LCa). However, not all heavy smokers develop these diseases and elevated cancer risk among first-degree relatives suggests an important role of genetic factor. Methods Three hundred and ten healthy blood donors (controls), 98 CAD, 74 UBCa and 38 LCa patients were included in this pilot study. The influence of 92 single nucleotide polymorphisms (SNPs) and impact of cigarette smoking were analysed. Results Out of 92 SNPs tested, differences in distribution of 14 SNPs were detected between controls and patient groups. Only CTLA4 rs3087243 showed difference in both CAD and UBCa patient group compared to control group. Stratified by smoking status, the impact of smoking was associated to frequencies of 8, 3 and 4 SNPs in CAD, UBCa, LCa patients, respectively. None of these 92 SNPs showed a statistically significant difference to more than one type of disease among smoking patients. In non-smoking patients, 7, 3 and 6 SNPs were associated to CAD, UBCa, LCa, respectively. Out of these 92 SNPs, CTLA4 rs3087243 was associated to both non-smoking CAD and UBCa. The XRCC1 rs25487 was associated to both non-smoking UBCa and LCa. Conclusion SNPs might be important risk factors for CAD, UBCa and LCa. Distribution of the SNPs was specific for each patient group, not a random event. Impact of cigarette smoking on the disease was associated to the specific SNP sequences. Thus, smoking individuals with SNPs associated to risk of these serious diseases is an important target group for smoking cessation programs.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

cytotoxic T lymphocyte antigen 4
DNA
DNA repair protein XRCC1
adult
aged
Article
bladder cancer
blood donor
cancer risk
cigarette smoking
controlled study
coronary artery disease
CTLA4 gene
female
genetic association
high risk population
human
lung cancer
major clinical study
male
molecular pathology
mutation rate
non-smoker
people by smoking status
pilot study
risk factor
single nucleotide polymorphism
smoking cessation program
XRCC1 gene
bladder tumor
case control study
genetic predisposition
genetics
lung tumor
middle aged
Case-Control Studies
Genetic Predisposition to Disease
Humans
Lung Neoplasms
Polymorphism
Single Nucleotide
Urinary Bladder Neoplasms

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Lewin, N. L.; Karlsson, Jan-Er ...; Robinsson, D.; Fagerberg, M.; Kentsson, M.; Sayardoust, Shar ...; visa fler...; Nilsson, Mats; Shamoun, L.; Andersson, B. -Å ...; Löfgren, S.; Rutqvist, L. E.; Lewin, F.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: PLOS ONE

Av lärosätet: Jönköping University; Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se