Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men

Lindgren, M.Department of Clinical Neurophysiology, Lund University and University Hospital (författare)

LIBRIS-ID:oai:DiVA.org:hkr-647
urn:nbn:se:hkr:diva-647urn
https://doi.org/10.1002/(SICI)1096-9136(199603)13:3<218::AID-DIA25>3.0.CO;2-DDOI
https://lup.lub.lu.se/record/1110229URI

The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.

SOCIAL SCIENCES Psychology Psychology (excluding Applied Psychology) hsv//eng
SAMHÄLLSVETENSKAP Psykologi Psykologi (exklusive tillämpad psykologi) hsv//swe
SAMHÄLLSVETENSKAP Psykologi hsv//swe
SOCIAL SCIENCES Psychology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Adult
Analysis of Variance
Blood Glucose/drug effects/metabolism
Cognition/*drug effects
Comparative Study
Electroencephalography/*drug effects
Epinephrine/*blood
Evoked Potentials
Auditory/drug effects
Evoked Potentials
Visual/drug effects
Human
Hypoglycemia/blood/chemically induced/*physiopathology
*Insulin/administration & dosage/pharmacology
Male
Reaction Time/drug effects
Reference Values
Single-Blind Method
Support
Non-U.S. Gov't
Cognitive science
Kognitionsforskning
SOCIAL SCIENCES
SAMHÄLLSVETENSKAP
Hypoglycaemia Cognitive Function

Eckert, B.Department of Internal Medicine, Lund University and University Hospital (författare)
Stenberg, Georg,1947-Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine (författare)
Agardh, C. D.Department of Internal Medicine, Lund University and University Hospital (författare)
Agardh, Carl-DavidLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-cag (författare)
Lindgren, M (författare)
Eckert, B (författare)
Department of Clinical Neurophysiology, Lund University and University HospitalDepartment of Internal Medicine, Lund University and University Hospital (creator_code:org_t)

Av författaren/redakt...: Lindgren, M.; Eckert, B.; Stenberg, Georg, ...; Agardh, C. D.; Agardh, Carl-Dav ...; Lindgren, M; visa fler...; Eckert, B; visa färre...

Om ämnet

SAMHÄLLSVETENSKAP: SAMHÄLLSVETENSKA ...; och Psykologi; och Psykologi exklus ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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