Sökning: onr:"swepub:oai:DiVA.org:hv-2757" >
Maternal hormones l...
-
Jansson, Nina,1976Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
(författare)
Maternal hormones linking maternal body mass index and dietary intake to birth weight.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
Bethesda, USA :American Society for Nutrition,2008
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:hv-2757
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2757URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20345URI
-
https://doi.org/10.1093/ajcn/87.6.1743DOI
-
https://gup.ub.gu.se/publication/71915URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: Obese women often give birth to large-for-gestational age infants (typically defined as a birth weight greater than the 90th percentile), who are at risk of birth injuries and of developing metabolic syndrome later in life. The mechanisms underlying increased fetal growth remain to be established. OBJECTIVE: We aimed to identify maternal hormones that can explain the link between dietary intake, body mass index (BMI), and birth weight. DESIGN: Pregnant women with BMIs (in kg/m(2)) ranging from 17 to 44 (n = 49) were recruited in gestational weeks 8-12. Serum hormone concentrations were measured and dietary history interviews were performed in the first and third trimesters. Multiple regression models were produced to identify hormones that correlate with birth weight and are influenced by BMI or dietary factors. RESULTS: We found a strong positive correlation between BMI and first- and third-trimester insulin and leptin concentrations and a negative correlation between BMI and first-trimester adiponectin and first- and third-trimester insulin-like growth factor binding protein-1 (IGFBP-1). Maternal total fat intake in the first trimester was positively correlated with maternal leptin and inversely correlated with adiponectin. In addition, third-trimester total fat intake was positively correlated with circulating resistin concentrations. First-trimester maternal serum resistin was positively correlated with birth weight, whereas third-trimester maternal IGFBP-1 was negatively correlated with birth weight. CONCLUSIONS: High first-trimester maternal serum resistin and low third-trimester IGFBP-1 were correlated with increased birth weight. We propose that low serum concentrations of IGFBP-1 represent a link between high BMI and increased fetal growth by increasing the bioavailability of insulin-like growth factor-I, which up-regulates placental nutrient transport.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Nilsfelt, AnnaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
(författare)
-
Gellerstedt, Martin,1966-Högskolan Väst,Institutionen för ekonomi och it,Department of Informatics, University West, Trollhättan, Sweden(Swepub:his)gelm
(författare)
-
Wennergren, Margareta,1948Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xwennm
(författare)
-
Rossander-Hulthén, Lena,1947Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för klinisk näringslära,Institute of Medicine, Department of Clinical Nutrition(Swepub:gu)xhulen
(författare)
-
Powell, Theresa L,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xpowth
(författare)
-
Jansson, Thomas,1955Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanst
(författare)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:American Journal of Clinical NutritionBethesda, USA : American Society for Nutrition87:6, s. 1743-90002-91651938-3207
Internetlänk
Hitta via bibliotek
Till lärosätets databas