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Sökning: onr:"swepub:oai:DiVA.org:kau-94660" > From Cohort to Coho...

  • Sapounidou, MariaUmeå universitet,Kemiska institutionen,Umeå universitet, Sverige,Umeå Univ, Dept Chem, SE-90187 Umeå, Sweden. (författare)

From Cohort to Cohort : A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-03-31
  • MDPI,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kau-94660
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-94660URI
  • https://doi.org/10.3390/toxics11040331DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-207870URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502661URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in children in a Swedish pregnancy cohort. A novel approach was proposed linking this epidemiological association with experimental evidence, where the effect of MIX N on thyroid hormone signaling was assessed using the Xenopus eleuthero-embryonic thyroid assay (XETA OECD TG248). From this experimental data, a point of departure (PoD) was derived based on OECD guidance. Our aim in the current study was to use updated toxicokinetic models to compare exposures of women of reproductive age in the US population to MIX N using a Similar Mixture Approach (SMACH). Based on our findings, 66% of women of reproductive age in the US (roughly 38 million women) had exposures sufficiently similar to MIX N. For this subset, a Similar Mixture Risk Index (SMRIHI) was calculated comparing their exposures to the PoD. Women with SMRIHI > 1 represent 1.1 million women of reproductive age. Older women, Mexican American and other/multi race women were less likely to have high SMRIHI values compared to Non-Hispanic White women. These findings indicate that a reference mixture of chemicals identified in a Swedish cohort—and tested in an experimental model for establishment of (PoDs)—is also of health relevance in a US population. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andersson, Patrik L.Umeå universitet,Kemiska institutionen,Umeå universitet, Sverige,Umeå Univ, Dept Chem, SE-90187 Umeå, Sweden.(Swepub:umu)paan0001 (författare)
  • Leemans, MichelleUMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France. (författare)
  • Fini, Jean-BaptisteUMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France. (författare)
  • Demeneix, BarbaraUMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France. (författare)
  • Rüegg, JoëlleUppsala universitet,Fysiologi och miljötoxikologi(Swepub:uu)joeru493 (författare)
  • Bornehag, Carl-Gustaf,1957-Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, USA,Faculty of Health, Science and Technology, Department of Health Sciences, Karlstad University, Karlstad, Sweden; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States,Karlstad Univ, Fac Hlth Sci & Technol, Dept Hlth Sci, SE-65188 Karlstad, Sweden.;Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.(Swepub:kau)caguborn (författare)
  • Gennings, ChrisIcahn School of Medicine at Mount Sinai, USA,Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States,Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA. (författare)
  • Umeå universitetKemiska institutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Toxics: MDPI11:42305-6304

Internetlänk

Hitta via bibliotek

  • Toxics (Sök värdpublikationen i LIBRIS)

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