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Changes in circulat...
Changes in circulating biomarkers during a single hemodialysis session
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Yamamoto, T. (författare)
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Nascimento, M. M. (författare)
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- Hayashi, Shirley Y. (författare)
- KTH,Medicinsk teknik
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visa fler...
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- Qureshi, A. R. (författare)
- Karolinska Institutet
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Waniewski, J. (författare)
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- Brodin, L. A. (författare)
- Karolinska Institutet
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Anderstam, B. (författare)
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Lind, B. (författare)
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Riella, M. C. (författare)
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Seeberger, A. (författare)
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Lindholm, B. (författare)
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visa färre...
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(creator_code:org_t)
- 2012-06-20
- 2013
- Engelska.
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Ingår i: Hemodialysis International. - : Wiley. - 1492-7535 .- 1542-4758. ; 17:1, s. 59-66
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ=0.61, P<0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies.
Nyckelord
- Cardiovascular disease
- Hemodialysis
- Interleukin-6
- Microinflammation
- Pentraxin-3
- Vascular calcification
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yamamoto, T.
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Nascimento, M. M ...
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Hayashi, Shirley ...
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Qureshi, A. R.
-
Waniewski, J.
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Brodin, L. A.
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visa fler...
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Anderstam, B.
-
Lind, B.
-
Riella, M. C.
-
Seeberger, A.
-
Lindholm, B.
-
visa färre...
- Artiklar i publikationen
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Hemodialysis Int ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet