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Carbohydrate-based ...
Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy
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- Neimert-Andersson, T. (författare)
- Karolinska Institutet
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- Thunberg, Sarah, 1976- (författare)
- Karolinska Institutet
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- Swedin, L. (författare)
- Karolinska Institutet, Sweden
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- Wiedermann, U. (författare)
- Medical University Vienna, Austria
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- Jacobsson-Ekman, G. (författare)
- Karolinska Institutet
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- Dahlen, S. -E (författare)
- Karolinska Institutet
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- Scheynius, A. (författare)
- Karolinska Institutet
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- Gronlund, H. (författare)
- Karolinska Institutet
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- van Hage, M. (författare)
- Karolinska Institutet
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- Gafvelin, G. (författare)
- Karolinska Institutet, Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2008
- 2008
- Engelska.
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 63:5, s. 518-526
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: Allergen-specific immunotherapy (ASIT) is the only treatment of allergic disease that gives long-lasting relief of symptoms. However, concerns for safety and efficiency have highlighted the need for improvement of the therapy. We have previously suggested carbohydrate-based particles (CBPs) as a novel adjuvant and allergen carrier for ASIT. Our aim of this study was to evaluate the therapeutic potential of CBPs in ASIT, employing a mouse model for cat allergy. Methods: BALB/c mice were subcutaneously immunized with the recombinant (r) cat allergen Fel d 1 followed by intranasal challenge with cat dander extract (CDE). The sensitized mice were therapeutically treated with rFel d 1 covalently coupled to CBPs (CBP-rFel d 1). Airway hyper-reactivity (AHR), infiltration of leucocytes in bronchoalveolar lavage (BAL) fluid, allergen-specific serum immunoglobulin levels and in vitro splenocyte responses were evaluated. Results: Mice treated with CBP-rFel d 1 showed reduced features of allergic inflammation. They responded with (i) significantly decreased AHR and infiltration of eosinophils in BAL fluid after CDE challenge, (ii) the serum level of rFel d 1-specific IgE was reduced and the level of IgG(2)a was more pronounced after CBP-rFel d 1 treatment, and (iii) there was also a tendency of decreased allergen-specific cellular response. Conclusions: Carbohydrate-based particles are effective tools as adjuvant and allergen carriers for use in ASIT and constitutes a promising strategy to improve allergy treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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Neimert-Andersso ...
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Thunberg, Sarah, ...
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Swedin, L.
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Wiedermann, U.
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Jacobsson-Ekman, ...
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Dahlen, S. -E
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visa fler...
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Scheynius, A.
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Gronlund, H.
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van Hage, M.
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Gafvelin, G.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Kungliga Tekniska Högskolan
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Karolinska Institutet