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Stabilized Cyclic P...
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Gunasekera, Sunithi,1977-Uppsala universitet,Farmakognosi
(författare)
Stabilized Cyclic Peptides as Scavengers of Autoantibodies : Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-04-09
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American Chemical Society (ACS),2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-238191
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-238191URI
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https://doi.org/10.1021/acschembio.8b00118DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358527URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138543614URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20181120
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The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope α-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fernandes-Cerqueira, C.Karolinska Institutet
(författare)
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Wennmalm, Stefan,1970-KTH,Experimentell biomolekylär fysik,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Scilifelab, Appl Phys, Expt Biomol Phys, Tomtebodavagen 23, S-17165 Stockholm, Sweden(Swepub:kth)u1wq1pdv
(författare)
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Wähämaa, H.Karolinska Institutet
(författare)
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Sommarin, Y.Eurodiagnost AB, S-21224 Malmo, Sweden
(författare)
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Catrina, A. I.Karolinska Institutet
(författare)
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Jakobsson, P. -JKarolinska Institutet
(författare)
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Göransson, Ulf,1970-Uppsala universitet,Farmakognosi(Swepub:uu)ugo29049
(författare)
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Uppsala universitetFarmakognosi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:ACS Chemical Biology: American Chemical Society (ACS)13:6, s. 1525-15351554-89291554-8937
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