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Sökning: onr:"swepub:oai:DiVA.org:kth-246295" > Genetic variants an...

  • Huang, KetuanGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)

Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • IVYSPRING INT PUBL,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-246295
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-246295URI
  • https://doi.org/10.7150/jca.28919DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20190325
  • Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Liao, XiwenGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Han, ChuangyeGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Wang, XiangkunGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Yu, TingdongGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Yang, ChengkunGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Liu, XiaoguangGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China. (författare)
  • Yu, LongGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450000, Henan, Peoples R China. (författare)
  • Chen, ZhiweiGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Qin, WeiGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Zhu, GuangzhiGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Su, HaoGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Liu, ZhengqianGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Zeng, XianminGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Zhou, XinGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Lu, SicongGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Huang, JianlvGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Nanning 530031, Guangxi, Peoples R China. (författare)
  • Liang, YuGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Liu, ZhengtaoKTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ju7n8n (författare)
  • Deng, JianlongGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi, Peoples R China. (författare)
  • Ye, XinpingGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Peng, TaoGuangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China. (författare)
  • Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Cancer: IVYSPRING INT PUBL10:6, s. 1453-14651837-9664

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