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Proteomic and Metab...
Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine
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- Herland, Anna (författare)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik,Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115 USA
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Maoz, Ben M. (författare)
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FitzGerald, Edward A. (författare)
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Grevesse, Thomas (författare)
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Vidoudez, Charles (författare)
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Sheehy, Sean P. (författare)
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Budnik, Nikita (författare)
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Dauth, Stephanie (författare)
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Mannix, Robert (författare)
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Budnik, Bogdan (författare)
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Parker, Kevin Kit (författare)
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Ingber, Donald E. (författare)
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(creator_code:org_t)
- 2020-08-03
- 2020
- Engelska.
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Ingår i: ADVANCED BIOSYSTEMS. - : Wiley. - 2366-7478. ; 4:9
- Relaterad länk:
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https://doi.org/10.1...
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The functional state of the neurovascular unit (NVU), composed of the blood-brain barrier and the perivasculature that forms a dynamic interface between the blood and the central nervous system (CNS), plays a central role in the control of brain homeostasis and is strongly affected by CNS drugs. Human primary brain microvascular endothelium, astrocyte, pericyte, and neural cell cultures are often used to study NVU barrier functions as well as drug transport and efficacy; however, the proteomic and metabolomic responses of these different cell types are not well characterized. Culturing each cell type separately, using deep coverage proteomic analysis and characterization of the secreted metabolome, as well as measurements of mitochondrial activity, the responses of these cells under baseline conditions and when exposed to the NVU-impairing stimulant methamphetamine (Meth) are analyzed. These studies define the previously unknown metabolic and proteomic profiles of human brain pericytes and lead to improved characterization of the phenotype of each of the NVU cell types as well as cell-specific metabolic and proteomic responses to Meth.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Herland, Anna
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Maoz, Ben M.
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FitzGerald, Edwa ...
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Grevesse, Thomas
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Vidoudez, Charle ...
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Sheehy, Sean P.
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visa fler...
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Budnik, Nikita
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Dauth, Stephanie
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Mannix, Robert
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Budnik, Bogdan
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Parker, Kevin Ki ...
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Ingber, Donald E ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
- Artiklar i publikationen
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ADVANCED BIOSYST ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Karolinska Institutet