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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07556naa a2200529 4500 | |
| 001 | oai:DiVA.org:kth-306416 | |
| 003 | SwePub | |
| 008 | 211216s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3064162 URI |
| 024 | 7 | a https://doi.org/10.15252/embr.2020509222 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhao, Li-Juanu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 245 | 1 0 | a Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness |
| 264 | c 2021-05-31 | |
| 264 | 1 | b EMBO,c 2021 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20211216 | |
| 520 | a Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein cargos of sEVs and their functions in recipient cells. This study demonstrates the presence of lysine-specific demethylase 1 (LSD1), which is the first identified histone demethylase, in the culture medium of gastric cancer cells. We show that sEVs derived from gastric cancer cells and the plasma of patients with gastric cancer harbor LSD1. The shuttling of LSD1-containing sEVs from donor cells to recipient gastric cancer cells promotes cancer cell stemness by positively regulating the expression of Nanog, OCT4, SOX2, and CD44. Additionally, sEV-delivered LSD1 suppresses oxaliplatin response of recipient cells in vitro and in vivo, whereas LSD1-depleted sEVs do not. Taken together, we demonstrate that LSD1-loaded sEVs can promote stemness and chemoresistance to oxaliplatin. These findings suggest that the LSD1 content of sEV could serve as a biomarker to predict oxaliplatin response in gastric cancer patients. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a gastric cancer | |
| 653 | a LSD1 | |
| 653 | a small extracellular vesicles | |
| 653 | a stemness | |
| 700 | 1 | a Li, Ying-Yingu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Zhang, Yu-Tongu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Fan, Qi-Qiu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Ren, Hong-Meiu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Zhang, Chengu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi4 aut0 (Swepub:kth)u1ww5kvp |
| 700 | 1 | a Mardinoglu, Adilu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England.4 aut0 (Swepub:kth)u1t8kmr6 |
| 700 | 1 | a Chen, Wen-Chaou Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Gastrointestinal Surg, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Pang, Jing-Ruu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Shen, Dan-Danu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Wang, Jun-Weiu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Zhao, Long-Feiu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Zhang, Jian-Yingu Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Wang, Zhen-Yau Zhengzhou Univ, Inst Drug Discovery & Dev, Key Lab Runliang Antiviral Medicines Res & Dev, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Zheng, Yi-Chaou Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 700 | 1 | a Liu, Hong-Minu Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.4 aut |
| 710 | 2 | a Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.b Science for Life Laboratory, SciLifeLab4 org |
| 773 | 0 | t EMBO Reportsd : EMBOg 22:8q 22:8x 1469-221Xx 1469-3178 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-306416 |
| 856 | 4 8 | u https://doi.org/10.15252/embr.202050922 |
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