Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients

Covid-19 in patients with chronic lymphocytic leukemia : clinical outcome and B- and T-cell immunity during 13 months in consecutive patients

QC 20220504
We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients from a well-defined area during month 1–13 of the pandemic. Sixty patients (median age 71 y, range 43–97) were identified. Median CIRS was eight (4–20). Patients had indolent CLL (n = 38), had completed (n = 12) or ongoing therapy (n = 10). Forty-six patients (77%) were hospitalized due to severe Covid-19 and 11 were admitted to ICU. Severe Covid-19 was equally distributed across subgroups irrespective of age, gender, BMI, CLL status except CIRS (p < 0.05). Fourteen patients (23%) died; age ≥75 y was the only significant risk factor (p < 0.05, multivariate analysis with limited power). Comparing month 1–6 vs 7–13 of the pandemic, deaths were numerically reduced from 32% to 18%, ICU admission from 37% to 15% whereas hospitalizations remained frequent (86% vs 71%). Seroconversion occurred in 33/40 patients (82%) and anti-SARS-CoV-2 antibodies were detectable at six and 12 months in 17/22 and 8/11 patients, respectively. Most (13/17) had neutralizing antibodies and 19/28 had antibodies in saliva. SARS-CoV-2-specific T-cells (ELISpot) were detected in 14/17 patients. Covid-19 continued to result in high admission even among consecutive and young early- stage CLL patients. A robust and durable B and/or T cell immunity was observed in most convalescents.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
anticoagulant agent
antineoplastic monoclonal antibody
bendamustine
Bruton tyrosine kinase inhibitor
corticosteroid
gamma interferon
hydroxychloroquine
hypertensive agent
immunoglobulin
immunoglobulin G antibody
neutralizing antibody
remdesivir
rituximab
SARS-CoV-2 antibody
SARS-CoV-2 convalescent plasma
tocilizumab
venetoclax
virus antibody
adult
aged
antibody response
Article
body mass
cellular immunity
chronic lymphatic leukemia
controlled study
coronavirus disease 2019
Cumulative Illness Rating Scale
enzyme linked immunospot assay
female
hospitalization
human
humoral immunity
intensive care
major clinical study
male
mortality rate
seroconversion
Sweden
B lymphocyte
blood
complication
follow up
immunology
isolation and purification
middle aged
multimodality cancer therapy
prognosis
T lymphocyte
very elderly
virology
Aged
80 and over
Antibodies
Neutralizing
Antibodies
Viral
B-Lymphocytes
Combined Modality Therapy
COVID-19
Follow-Up Studies
Humans
Leukemia
Lymphocytic
Chronic
B-Cell
SARS-CoV-2
T-Lymphocytes

Bogdanovic, G. (författare)
Buggert, M.Karolinska Institutet (författare)
Gao, Y.Karolinska Institutet (författare)
Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi(Swepub:kth)u11qqzc1 (författare)
Healy, K. (författare)
Johansson, H.Karolinska Institutet (författare)
Kjellander, C.Karolinska Institutet (författare)
Mravinacová, SáraKarolinska Institutet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1utu00u (författare)
Muschiol, S.Karolinska Institutet (författare)
Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1ws88sk (författare)
Palma, M.Karolinska Institutet (författare)
Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1pmjyje (författare)
Smith, C. I. E.Karolinska Institutet (författare)
Stromberg, O. (författare)
Sällberg Chen, M. (författare)
Zain, R.Karolinska Institutet (författare)
Hansson, L. (författare)
Österborg, A.Karolinska Institutet (författare)
Karolinska InstitutetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

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