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Mapping the subcell...
Mapping the subcellular protein distribution in three human cell lines
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- Fagerberg, Linn (författare)
- KTH,Proteomik
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- Sandler, Charlotte (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Skogs, Marie (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Hjelmare, Martin (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Jonasson, Kalle (författare)
- KTH,Proteomik
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- Wiking, Mikaela (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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- Åbergh, Annica (författare)
- KTH,Proteomik
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- Uhlén, Mathias (författare)
- KTH,Proteomik,Science for Life Laboratory, SciLifeLab
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- Lundberg, Emma (författare)
- KTH,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2011-06-29
- 2011
- Engelska.
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Ingår i: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 10:8, s. 3766-3777
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The subcellular locations of proteins are closely related to their function and constitute an essential aspect for understanding the complex machinery of living cells. A systematic effort has been initiated to map the protein distribution in three functionally different cell lines with the aim to provide a subcellular localization index for at least one representative protein from all human protein-encoding genes. Here, we present the results of over 4,000 proteins mapped to 16 subcellular compartments. The results indicate a ubiquitous protein expression with a majority of the proteins found in all three cell lines and a large portion localized to two or more compartments. The inter-relationships between the subcellular compartments are visualized in a protein-compartment network based on all detected proteins. Hierarchical clustering was performed to determine how closely related the organelles are in terms of protein constituents and compare the proteins detected in each cell type. Our results show distinct organelle proteomes, well conserved across the cell types, and demonstrate that biochemically similar organelles are grouped together.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Nyckelord
- antibody
- organelle
- Human Protein Atlas
- subcellular atlas
- immunofluorescence
- confocal microscopy
- Bioengineering
- Bioteknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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