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Electrohydraulic Va...
Electrohydraulic Vascular Compression Device (e-VaC) with Integrated Sensing and Controls
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2022-11-13
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Wiley,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-329003
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-329003URI
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https://doi.org/10.1002/admt.202201196DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20230614
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Right ventricular (RV) failure remains a significant clinical burden particularly during the perioperative period surrounding major cardiac surgeries, such as implantation of left ventricular assist devices (LVADs), bypass procedures or valvular surgeries. Device solutions designed to support the function of the RV do not keep up with the pace of development of left-sided solutions, leaving the RV vulnerable to acute failure in the challenging hemodynamic environments of the perioperative setting. This work describes the design of a biomimetic, soft, conformable sleeve that can be prophylactically implanted on the pulmonary artery to support RV ventricular function during major cardiac surgeries, through afterload reduction and augmentation of flow. Leveraging electrohydraulic principles, a technology is proposed that is non-blood contacting and obviates the necessity for drivelines by virtue of being electrically powered. In addition, the integration of an adjacent is demonstrate, continuous pressure sensing module to support physiologically adaptive control schemes based on a real-time biological signal. In vitro experiments conducted in a pulsatile flow-loop replicating physiological flow and pressure conditions show a reduction of mean pulmonary arterial pressure of 8 mmHg (25% reduction), a reduction in peak systolic arterial pressure of up to 10 mmHg (20% reduction), and a concomitant 19% increase in diastolic pulmonary flow. Computational simulations further predict substantial augmentation of cardiac output as a result of reduced RV ventricular stress and RV dilatation.
Ämnesord och genrebeteckningar
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TEKNIK OCH TEKNOLOGIER Medicinteknik hsv//swe
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ENGINEERING AND TECHNOLOGY Medical Engineering hsv//eng
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continuous sensing
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electrohydraulic actuator
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mechanical cardiac support
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right ventricular failure
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Artificial heart
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Biomimetics
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Cardiovascular surgery
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Failure (mechanical)
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Heart
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Hydraulic actuators
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Left ventricular assist devices
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Mechanical actuators
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% reductions
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Cardiac-surgery
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Compression devices
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Electro-hydraulic actuator
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Electro-hydraulics
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Mechanical
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Right ventricular
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Hydraulics
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kight, A.
(författare)
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Liang, X.
(författare)
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Han, A. K.
(författare)
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Ennis, D. B.
(författare)
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Hiesinger, W.
(författare)
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Dual, Seraina A.KTH,Medicinteknik och hälsosystem(Swepub:kth)u1zh79lk
(författare)
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Cutkosky, M. R.
(författare)
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KTHMedicinteknik och hälsosystem
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Advanced Materials Technologies: Wiley8:4, s. 2201196-2365-709X
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