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Novel tetrahydronap...
Novel tetrahydronaphthalen-1-yl-phenethyl ureas : synthesis and dual antibacterial-anticancer activities
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- Akbaba, Yusuf (författare)
- Erzurum Tech Univ, Fac Sci, Dept Basic Sci, Erzurum, Turkiye.
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- Kaci, Fatma Necmiye (författare)
- Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye.;St James Univ Hosp, Univ Leeds, Fac Med & Hlth, Leeds, England.
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- Arslan, Mehmet Enes (författare)
- Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye.
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- Goksu, Suleyman (författare)
- Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkiye.
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.;KTH Royal Inst Technol, Sci Life Lab, SE-17121 Stockholm, Sweden.
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- Turkez, Hasan (författare)
- Ataturk Univ, Fac Med, Dept Med Biol, Erzurum, Turkiye.
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Erzurum Tech Univ, Fac Sci, Dept Basic Sci, Erzurum, Turkiye Erzurum Tech Univ, Fac Sci, Dept Mol Biol & Genet, Erzurum, Turkiye.;St James Univ Hosp, Univ Leeds, Fac Med & Hlth, Leeds, England. (creator_code:org_t)
- Informa UK Limited, 2024
- 2024
- Engelska.
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Ingår i: Journal of enzyme inhibition and medicinal chemistry (Print). - : Informa UK Limited. - 1475-6366 .- 1475-6374. ; 39:1
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cancer and antibiotic-resistant bacterial infections are significant global health challenges. The resistance developed in cancer treatments intensifies therapeutic difficulties. In addressing these challenges, this study synthesised a series of N,N '-dialkyl urea derivatives containing methoxy substituents on phenethylamines. Using isocyanate for the efficient synthesis yielded target products 14-18 in 73-76% returns. Subsequently, their antibacterial and anticancer potentials were assessed. Cytotoxicity tests on cancer cell lines, bacterial strains, and a healthy fibroblast line revealed promising outcomes. All derivatives demonstrated robust antibacterial activity, with MIC values ranging from 0.97 to 15.82 mu M. Notably, compounds 14 and 16 were particularly effective against the HeLa cell line, while compounds 14, 15, and 17 showed significant activity against the SH-SY5Y cell line. Importantly, these compounds had reduced toxicity to healthy fibroblast cells than to cancer cells, suggesting their potential as dual-functioning agents targeting both cancer and bacterial infections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Antibacterial activity
- anticancer activity
- isocyanates
- N
- N'-dialkyl urea
- phenethylamine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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