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Estrogen receptor b...
Estrogen receptor beta expression and role in cancers
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- Monteiro, Fátima Liliana (författare)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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- Stepanauskaite, Lina (författare)
- Karolinska Institutet,KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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- Archer, Amena (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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- Williams, Cecilia, Professor, 1969- (författare)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden
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(creator_code:org_t)
- Elsevier BV, 2024
- 2024
- Engelska.
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Ingår i: Journal of Steroid Biochemistry and Molecular Biology. - : Elsevier BV. - 0960-0760 .- 1879-1220. ; 242
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Estrogen drives the growth of some cancers, such as breast cancer, via estrogen receptor alpha (ERα). Estrogen also activates ERβ, but whether ERβ is expressed and has a role in different cancers is debated. The use of nonspecific antibodies has contributed to the confusion, and this review delves into ERβ's controversial role in cancer and focuses on tumor expression that can be supported by non-antibody-dependent assays. We discuss its expression at the transcript level and focus on its potential role in lymphoma, granulosa cell tumors, testicular, and adrenal cancers, emphasizing recent findings and the complexities that necessitate further research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer
- ESR2
- isoforms
- Estrogen receptor beta
- expression
- microenvironment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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