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The significance of...
The significance of gap junction location in striatal fast spiking interneurons
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- Hjorth, Johannes (författare)
- Karolinska Institutet,KTH,Beräkningsbiologi, CB
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- Elias, Alex Hanna (författare)
- KTH,Beräkningsbiologi, CB
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- Hellgren Kotaleski, Jeanette (författare)
- KTH,Beräkningsbiologi, CB
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Neurocomputing. - : Elsevier BV. - 0925-2312 .- 1872-8286. ; 70:10-12, s. 1887-1891
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Fast spiking (FS) interneurons in the striatunt are hypothesised to control spike timing in the numerous medium spiny (MS) projection neurons by inhibiting or delaying firing in the MS neurons. The FS neurons are connected to each other through electrical gap junctions. This might synchronise the FS neurons, leading to increased influence on target neurons. Here, we explore the possible difference between proximal and distal gap junction locations. Somatic and distal dendritic gap junctions with equal effective coupling coefficient, as defined for steady-state somatic inputs, showed significantly different effective coupling coefficient with transient inputs. However, the ability to synchronise spiking in pairwise coupled FS neurons, which received synaptic inputs as during striatal up-state periods, was as effective with distal gap junctions as with proximal ones. Proximal gap junctions, however, caused synchronisation within a more precise time window.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Datavetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Computer Sciences (hsv//eng)
Nyckelord
- striatum; fast spiking interneurons; gap junctions; synchronisation
- Computer science
- Datalogi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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