Identification of the mechanical parameters for the human uterus in vivo using intrauterine pressure measurements

• There are limited experimental data to characterize the mechanical response of human myometrium. A method is presented in this work to identify mechanical parameters describing the active response of human myometrium from the in vivo intrauterine pressure measurements. A finite element model is developed to compute the intrauterine pressure during labor in response to an increase in the intracellular calcium ion concentration within myometrial smooth muscle cells. The finite element model provides the opportunity to tune mechanical parameters in order to fit the computed intrauterine pressure to in vivo measurements. Since the model is computationally expensive, a cheaper meta-model is generated to approximate the model response. By fitting the meta-model response to the in vivo measurements, the parameters used to determine the active response of human myometrial smooth muscle are identified.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik -- Teknisk mekanik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering -- Applied Mechanics (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering (hsv//eng)

Nyckelord

human uterine smooth muscle mechanics

intrauterine pressure

parameter identification

response surface methodology

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