Sökning: onr:"swepub:oai:DiVA.org:liu-121427" > Increased humoral i...
Fältnamn | Indikatorer | Metadata |
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000 | 06484naa a2200481 4500 | |
001 | oai:DiVA.org:liu-121427 | |
003 | SwePub | |
008 | 150918s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1214272 URI |
024 | 7 | a https://doi.org/10.1136/gutjnl-2013-3062362 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Vicario, Mariau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut |
245 | 1 0 | a Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations |
264 | c 2014-09-10 | |
264 | 1 | b BMJ PUBLISHING GROUP,c 2015 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Fondo de Investigacion Sanitaria; CIBERehd, Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, Ministerio de Economia y Competitividad [CP10/00502, PI13/00935, CM08/00229, CM10/00155, FI12/00254, PI12/00314, EII2011-0035, PI11/00716]; Ministerio de Educacion, Direccion General de Investigacion [SAF 2009-07416]; Agencia de Gestio dAjuts Universitaris i de Recerca, de la Generalitat de Catalunya [2009 SGR 219, 2011 BP/A00099]; Rome Foundation; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas [CB06/04/0021] | |
520 | a Background and aims Altered intestinal barrier is associated with immune activation and clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production and its contribution to IBS aetiopathogenesis remain undefined. This study evaluated the role of humoral activity in IBS-D. Methods A single mucosal jejunal biopsy, luminal content and blood were obtained from healthy volunteers (H; n = 30) and IBS-D (n = 49; Rome III criteria) participants. Intraepithelial lymphocytes, mast cells, B lymphocytes and plasma cells were studied by imaging techniques. Differential gene expression and pathway analysis were assessed by microarray and PCR techniques. Blood and luminal immunoglobulins (Igs) were quantified. Gastrointestinal symptoms, respiratory atopy and stress and depression were also recorded. Results Patients with IBS-D showed a higher number and activation of mucosal B lymphocytes and plasma cells (p less than 0.05). Mast cell density was increased in patients with IBS-D (non-atopic) and in close proximity to plasma cells (p less than 0.05). Microarray profiling identified differential humoral activity in IBS-D, involving proliferation and activation of B lymphocytes and Igs production (p less than 0.001). Mucosal humoral activity was higher in IBS-D, with upregulation of germline transcripts and Ig genes (1.3-fold-1.7-fold increase; p less than 0.05), and increased IgG(+) cells and luminal IgG compared with H (p less than 0.05), with no differences in blood. Biological markers of humoral activity correlated positively with bowel movements, stool form and depression. Conclusions Enhanced small bowel humoral immunity is a distinctive feature of IBS-D. Mucosal Ig production contributes to local inflammation and clinical manifestations in IBS-D. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Gonzalez-Castro, Ana M.u Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Martinez, Cristinau Heidelberg University, Germany4 aut |
700 | 1 | a Lobo, Beatrizu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Pigrau, Marcu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Guilarte, Maru University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a de Torres, Inesu University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Mosquera, Jose L.u University of Barcelona, Spain4 aut |
700 | 1 | a Fortea, Marinau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Sevillano-Aguilera, Cesaru Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Salvo-Romero, Eloisau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Alonso, Carmenu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut |
700 | 1 | a Rodino-Janeiro, Bruno K.u Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut |
700 | 1 | a Söderholm, Johan D.u Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)sodda63 |
700 | 1 | a Azpiroz, Fernandou Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut |
700 | 1 | a Santos, Javieru Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut |
710 | 2 | a Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spainb Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 org |
773 | 0 | t Gutd : BMJ PUBLISHING GROUPg 64:9, s. 1379-1388q 64:9<1379-1388x 0017-5749x 1468-3288 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121427 |
856 | 4 8 | u https://doi.org/10.1136/gutjnl-2013-306236 |
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