Sökning: onr:"swepub:oai:DiVA.org:liu-122723" >
Lipoprotein profile...
-
Ljunggren, Stefan ALinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
(författare)
Lipoprotein profiles in human heterozygote carriers of a functional mutation P297S in scavenger receptor class B1.
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
-
Elsevier,2015
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-122723
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122723URI
-
https://doi.org/10.1016/j.bbalip.2015.09.006DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding agencies: EUs Sixth Framework Program [037631]; European Union [FP7-603091-2]; CardioVascular Research Initiative [CVON2011-16]; Research Council of South East Sweden [FORSS-3755]; County Council of Ostergotland (C-ALF); Faculty of Health Sciences in Linkoping; Ven
-
The scavenger receptor class B type 1 (SR-B1) is an important HDL receptor involved in cholesterol uptake and efflux, but its physiological role in human lipoprotein metabolism is not fully understood. Heterozygous carriers of the SR-B1P297S mutation are characterized by increased HDL cholesterol levels, impaired cholesterol efflux from macrophages and attenuated adrenal function. Here, the composition and function of lipoproteins were studied in SR-B1P297S heterozygotes.Lipoproteins from six SR-B1P297S carriers and six family controls were investigated. HDL and LDL/VLDL were isolated by ultracentrifugation and proteins were separated by two-dimensional gel electrophoresis and identified by mass spectrometry. HDL antioxidant properties, paraoxonase 1 activities, apoA-I methionine oxidations and HDL cholesterol efflux capacity were assessed.Multivariate modeling separated carriers from controls based on lipoprotein composition. Protein analyses showed a significant enrichment of apoE in LDL/VLDL and of apoL-1 in HDL from heterozygotes compared to controls. The relative distribution of plasma apoE was increased in LDL and in lipid-free form. There were no significant differences in paraoxonase 1 activities, HDL antioxidant properties or HDL cholesterol efflux capacity but heterozygotes showed a significant increase of oxidized methionines in apoA-I.The SR-B1P297S mutation affects both HDL and LDL/VLDL protein compositions. The increase of apoE in carriers suggests a compensatory mechanism for attenuated SR-B1 mediated cholesterol uptake by HDL. Increased methionine oxidation may affect HDL function by reducing apoA-I binding to its targets. The results illustrate the complexity of lipoprotein metabolism that has to be taken into account in future therapeutic strategies aiming at targeting SR-B1.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Levels, Johannes H MAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Hovingh, KeesAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Holleboom, Adriaan GAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Vergeer, MennoAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Argyri, LettaNational Center for Scientific Research "Demokritos", Athens, Greece
(författare)
-
Gkolfinopoulou, ChristinaNational Center for Scientific Research "Demokritos", Athens, Greece
(författare)
-
Chroni, AngelikiNational Center for Scientific Research "Demokritos", Athens, Greece
(författare)
-
Sierts, Jeroen AAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Kastelein, John JAcademic Medical Centre, Amsterdam, the Netherlands
(författare)
-
Kuivenhoven, Jan AlbertUniversity of Groningen, University Medical Center Groningen, Groningen, the Netherlands
(författare)
-
Lindahl, MatsLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)matli17
(författare)
-
Karlsson, HelenLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin(Swepub:liu)helka90
(författare)
-
Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids: Elsevier1851:12, s. 1587-15951388-19811879-2618
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ljunggren, Stefa ...
-
Levels, Johannes ...
-
Hovingh, Kees
-
Holleboom, Adria ...
-
Vergeer, Menno
-
Argyri, Letta
-
visa fler...
-
Gkolfinopoulou, ...
-
Chroni, Angeliki
-
Sierts, Jeroen A
-
Kastelein, John ...
-
Kuivenhoven, Jan ...
-
Lindahl, Mats
-
Karlsson, Helen
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biokemi och mole ...
- Artiklar i publikationen
-
Biochimica et Bi ...
- Av lärosätet
-
Linköpings universitet