Sökning: onr:"swepub:oai:DiVA.org:liu-13526" >
Effects on intersti...
-
Dizdar (Dizdar Segrell), NilLinköpings universitet,Neurologi,Hälsouniversitetet
(författare)
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants
- Artikel/kapitelEngelska1997
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-13526
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13526URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Using microdialysis of human melanoma transplants in athymic mice we have shown that interstitial glutathione levels decreased during treatment with buthionine sulphoximine (BSO) and recovered after cessation of treatment. The cysteine concentrations also decreased, while 5-S-cysteinyldopa tended to increase during BSO treatment. Restoration of the glutathione levels was not seen after either N-acetylcysteine (NAC) or L-2-oxothiazolidine-4-carboxylate (OTC) injections, given on the third day of BSO treatment. These results were to be expected since NAC and OTC were given during the BSO treatment, and BSO is a specific and potent inhibitor of glutathione synthesis. Cysteine levels, however, increased after the NAC injection but remained unaltered after the OTC injection, while 5-S-cysteinyldopa remained unaltered after both the NAC and the OTC injections.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kullman, AnitaLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)aniku95
(författare)
-
Kågedal, BertilLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)berka70
(författare)
-
Årstrand, KerstinLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)kerar67
(författare)
-
Linköpings universitetNeurologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Melanoma research7:4, s. 322.-3280960-89311473-5636
Internetlänk
Hitta via bibliotek
Till lärosätets databas