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Structural advances...
Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding.
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- Zacharchenko, Thomas (författare)
- Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
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- von Castelmur, Eleonore (författare)
- Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, Netherlands Cancer Institute, Amsterdam, Netherlands
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- Rigden, Daniel J (författare)
- Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
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- Mayans, Olga (författare)
- Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
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(creator_code:org_t)
- Portland Press Ltd, 2015
- 2015
- Engelska.
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Ingår i: Biochemical Society Transactions. - : Portland Press Ltd. - 0300-5127 .- 1470-8752. ; 43:5, s. 850-5
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- crystal structure
- multi-Ig tandem
- protein nanofibre
- protein scaffold
- titin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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