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Ratiometric fluorog...
Ratiometric fluorogenic determination of endogenous hypochlorous acid in living cells
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- Hu, Jiwen (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Shanghai Univ, Peoples R China
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- Zhang, Xin (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Liu, Tingting (författare)
- Tongji Univ, Peoples R China
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- Gao, Hong-Wen (författare)
- Tongji Univ, Peoples R China
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- Lu, Senlin (författare)
- Shanghai Univ, Peoples R China
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- Uvdal, Kajsa (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten
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- Hu, Zhang-Jun (författare)
- Linköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten,Shanghai Univ, Peoples R China
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2019
- 2019
- Engelska.
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Ingår i: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. - : PERGAMON-ELSEVIER SCIENCE LTD. - 1386-1425 .- 1873-3557. ; 219, s. 232-239
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hypochlorous acid (HClO) is one of the most important ROS (reactive oxygen species) and common pollutant in tap-water. However, the determination of HClO with fast response and high sensitivity/selectivity is still an urgent demanding. Here we fabricated a ratiometric fluorescent probe RC based on TBET (through-bond energy transfer) on the platform of coumarin and rhodamine with the thiosemicarbazide group as the linker. This probe could display the characteristic fluorescence emission of coumarin. Upon addition of HClO, the linker was reacted into an oxadiazole, resulting in the opening of spiro-ring of rhodamine. The resultant then gives ratiometric fluorogenic changes. The probe exhibits fast response and high selectivity and sensitivity towards HClO with a low limit of detection (similar to 140 nM). Eventually, RC is successfully applicated for determining spiked HClO in water samples and imaging endogenous HClO in living cells. (C) 2019 Published by Elsevier B.V.
Ämnesord
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Nyckelord
- Coumarin; Rhodamine; Hypochlorous acid; Ratiometric; Fluorescence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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