Sökning: onr:"swepub:oai:DiVA.org:liu-171952" > Treatment of severe...
Fältnamn | Indikatorer | Metadata |
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000 | 05164naa a2200637 4500 | |
001 | oai:DiVA.org:liu-171952 | |
003 | SwePub | |
008 | 201216s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:145189963 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1719522 URI |
024 | 7 | a https://doi.org/10.7150/thno.483422 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1451899632 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Han, Young Joou Sungkyunkwan Univ, South Korea4 aut |
245 | 1 0 | a Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials |
264 | 1 | b IVYSPRING INT PUBL,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-beta 1b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a COVID-19; therapeutic agent; SARS; MERS; mortality; coronavirus | |
700 | 1 | a Lee, Keum Hwau Yonsei Univ, South Korea4 aut |
700 | 1 | a Yoon, Sojungu Yonsei Univ, South Korea4 aut |
700 | 1 | a Nam, Seoung Wanu Yonsei Univ, South Korea4 aut |
700 | 1 | a Ryu, Seohyunu Yonsei Univ, South Korea4 aut |
700 | 1 | a Seong, Dawonu Yonsei Univ, South Korea4 aut |
700 | 1 | a Kim, Jae Seoku Yonsei Univ, South Korea4 aut |
700 | 1 | a Lee, Jun Youngu Yonsei Univ, South Korea4 aut |
700 | 1 | a Yang, Jae Wonu Yonsei Univ, South Korea4 aut |
700 | 1 | a Lee, Jinheeu Yonsei Univ, South Korea4 aut |
700 | 1 | a Koyanagi, Aiu Univ Barcelona, Spain; ICREA, Spain4 aut |
700 | 1 | a Hong, Sung Hwiu Harvard TH Chan Sch Publ Hlth, MA USA4 aut |
700 | 1 | a Dragioti, Elenau Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum4 aut0 (Swepub:liu)eledr71 |
700 | 1 | a Radua, Joaquimu Karolinska Institutet4 aut |
700 | 1 | a Smith, Leeu Anglia Ruskin Univ, England4 aut |
700 | 1 | a Oh, Hansu Univ Southern Calif, CA 90089 USA4 aut |
700 | 1 | a Abou Ghayda, Ramyu Harvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA4 aut |
700 | 1 | a Kronbichler, Andreasu Med Univ Innsbruck, Austria4 aut |
700 | 1 | a Effenberger, Mariau Med Univ Innsbruck, Austria4 aut |
700 | 1 | a Kresse, Danielau St Johann Cty Hosp, Austria4 aut |
700 | 1 | a Denicolo, Sarau Med Univ Innsbruck, Austria4 aut |
700 | 1 | a Kang, Woosunu Univ Illinois, IL USA4 aut |
700 | 1 | a Jacob, Louisu Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France4 aut |
700 | 1 | a Shin, Hanwulu Yonsei Univ, South Korea4 aut |
700 | 1 | a Shin, Jae Ilu Yonsei Univ, South Korea4 aut |
710 | 2 | a Sungkyunkwan Univ, South Koreab Yonsei Univ, South Korea4 org |
773 | 0 | t Theranosticsd : IVYSPRING INT PUBLg 11:3, s. 1207-1231q 11:3<1207-1231x 1838-7640 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1510466/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://europepmc.org/articles/pmc7738873?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171952 |
856 | 4 8 | u https://doi.org/10.7150/thno.48342 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145189963 |
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