Wide-field mosaics of the corneal subbasal nerve plexus in Parkinsons disease using in vivo confocal microscopy

Funding Agencies|Hofgrens fond, NEURO Sweden; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)German Research Foundation (DFG) [273371152]
In vivo confocal microscopy (IVCM) is a non-invasive imaging technique facilitating real-time acquisition of images from the live cornea and its layers with high resolution (1-2 mu m) and high magnification (600 to 800-fold). IVCM is extensively used to examine the cornea at a cellular level, including the subbasal nerve plexus (SBNP). IVCM of the cornea has thus gained intense interest for probing ophthalmic and systemic diseases affecting peripheral nerves. One of the main drawbacks, however, is the small field of view of IVCM, preventing an overview of SBNP architecture and necessitating subjective image sampling of small areas of the SBNP for analysis. Here, we provide a high-quality dataset of the corneal SBNP reconstructed by automated mosaicking, with an average mosaic image size corresponding to 48 individual IVCM fields of view. The mosaic dataset represents a group of 42 individuals with Parkinsons disease (PD) with and without concurrent restless leg syndrome. Additionally, mosaics from a control group (n = 13) without PD are also provided, along with clinical data for all included participants.

Allgeier, StephanKarlsruhe Inst Technol KIT, Germany (författare)
Scarpa, FabioUniv Padua, Italy (författare)
Andreasson, MattiasKarolinska Institutet (författare)
Bartschat, AndreasKarlsruhe Inst Technol KIT, Germany (författare)
Mikut, RalfKarlsruhe Inst Technol KIT, Germany (författare)
Colonna, AlessiaUniv Padua, Italy (författare)
Belissario, MarcoLinköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten(Swepub:liu)marbe79 (författare)
Utheim, Tor PaaskeOslo Univ Hosp, Norway; Sorlandet Hosp Arendal, Norway (författare)
Köhler, BerndKarlsruhe Inst Technol KIT, Germany (författare)
Svenningsson, PerKarolinska Institutet (författare)
Lagali, NeilLinköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,Sorlandet Hosp Arendal, Norway(Swepub:liu)neina50 (författare)
Oslo Univ Hosp, NorwayKarlsruhe Inst Technol KIT, Germany (creator_code:org_t)

Av författaren/redakt...: Badian, Reza A.; Allgeier, Stepha ...; Scarpa, Fabio; Andreasson, Matt ...; Bartschat, Andre ...; Mikut, Ralf; visa fler...; Colonna, Alessia; Belissario, Marc ...; Utheim, Tor Paas ...; Köhler, Bernd; Svenningsson, Pe ...; Lagali, Neil; visa färre...

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