Targeting malignant glioma cells in vitro using platelet-derived growth factor AA-based conjugates

Dahlström Wester, MariaLinköpings universitet,Cellbiologi,Hälsouniversitetet (författare)

Glioblastoma multiforme (GBM) is an unusually aggressive brain tumor; it is also highly heterogeneous. Poor prognosis and a median survival of less than 1 year, using conventional treatment, calls for development of new treatment strategies. Overexpression and/or amplification of platelet-derived growth factor alpha receptors (PDGFalphaRs) in GBM might act as potential targets for a novel therapeutic approach. In this study, conjugates based on PDGFAA-ligand and dextran, of different sizes (10 and 40 kDa dextran), were prepared and investigated regarding targeting properties in vitro. Three human malignant glioma cell lines, U343MGa31L, U343MGaCl2:6, and U563MG, were used because of their previously reported differences in receptor expression and behavior. PDGFAA-based 10 kDa dextran iodine-125 radiolabeled conjugates showed the most favorable properties according to results achieved in accumulation, retention, and localization of cell-associated radioactivity. In comparison with dextran-(125)I-tyrosine delivered radioactivity, the PDGFAA-based dextran conjugates confirm the potential of receptor targeting.

Wasteson, ÅkeLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)akewa07 (författare)
Lindström, AnnelieLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)annli74 (författare)
Linköpings universitetCellbiologi (creator_code:org_t)

Ingår i:Journal of drug targeting: Informa UK Limited, s. 1-101029-23301061-186X

Av författaren/redakt...: Dahlström Wester ...; Wasteson, Åke; Lindström, Annel ...

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