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Sökning: onr:"swepub:oai:DiVA.org:liu-184709" > Hepatocyte growth f...

  • Bäckryd, EmmanuelLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Pain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden (författare)

Hepatocyte growth factor, colony-stimulating factor 1, CD40, and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-08-24
  • LIPPINCOTT WILLIAMS & WILKINS,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-184709
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184709URI
  • https://doi.org/10.1097/j.pain.0000000000002451DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451521URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|NEURO Sweden; ALF Research Grants, Region Ostergotland; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02470]; European CommissionEuropean CommissionEuropean Commission Joint Research Centre [ID633491]; International Diabetic Neuropathy Consortium - Novo Nordisk Foundation [NNF14SA0006]; Academy of Medical Sciences Starter Grant [SGL022\1086]
  • One in 5 patients with diabetes suffers from chronic pain with neuropathic characteristics, but the pathophysiological mechanisms underlying the development of neuropathic pain in patients with diabetic distal symmetrical polyneuropathy (DSP) are poorly understood. Systemic low-grade inflammation has been implicated, but there is still a considerable knowledge gap concerning its scope and meaning in this context. The aim of the study was to establish the broad inflammatory signature of painful diabetic DSP in serum samples from the Pain in Neuropathy Study, an observational cross-sectional multicentre study in which participants underwent deep phenotyping. In the present two cohorts exploration-replication study (180 participants in each cohort), serum samples from Pain in Neuropathy Study participants were analyzed with the Olink INFLAMMATION panel (Olink Bioscience, Uppsala, Sweden) that enables the simultaneous measurement of 92 inflammation-related proteins (mainly cytokines, chemokines, and growth factors). In both the exploration and the replication cohort, we identified a high-inflammation subgroup where 14 inflammation-related proteins in particular were associated with more neuropathy and higher pain intensity. The top 3 proteins were hepatocyte growth factor, colony-stimulating factor 1, and CD40 in both cohorts. In the exploratory cohort, additional clinical data were available, showing an association of inflammation with insomnia and self-reported psychological distress. Hence, this cross-sectional exploration-replication study seems to confirm that low-grade systemic inflammation is related to the severity of neuropathy and neuropathic pain in a subgroup of patients with diabetic DSP. The pathophysiological relevance of these proteins for the development of neuropathic pain in patients with diabetic DSP must be explored in more depth in future studies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Themistocleous, AndreasUniv Oxford, England,Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK (författare)
  • Larsson, AndersUppsala universitet,Klinisk kemi,Uppsala Univ, Sweden(Swepub:uu)andlarss (författare)
  • Gordh, TorstenUppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden(Swepub:uu)torsgord (författare)
  • Rice, Andrew S. C.Imperial Coll London, England,Pain Research, Dept Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom (författare)
  • Tesfaye, SolomonSheffield Teaching Hosp NHS Fdn Trust, England,Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (författare)
  • Bennett, David L.Univ Oxford, England,Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK (författare)
  • Gerdle, BjörnLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Pain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:liu)bjoge88 (författare)
  • Linköpings universitetAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pain: LIPPINCOTT WILLIAMS & WILKINS163:5, s. 897-9090304-39591872-6623

Internetlänk

Hitta via bibliotek

  • Pain (Sök värdpublikationen i LIBRIS)

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