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  • Gualandro, Danielle M. M.Univ Basel, Switzerland; Univ Hosp Basel, Switzerland; Univ Sao Paulo, Brazil (författare)

Acute heart failure after non-cardiac surgery: incidence, phenotypes, determinants and outcomes

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023-02-07
  • WILEY,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-192324
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192324URI
  • https://doi.org/10.1002/ejhf.2773DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Swiss National Science Foundation; Swiss Heart Foundation; University Hospital Basel; University of Basel; AstraZeneca; Abbott; Roche; Clinical Research Program of the University of Basel; Spezialprogramm Nachwuchsforderung Klinische Forschung; Forderung Exzellenter Junger Forschender; Forschung fond Kantonsspital Aarau; Swiss Academy of Medical Sciences; Bangerter Foundation; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo; Brazil [FAPESP] [2015/23731-6]; Swedish Research Council [2019-02833]; South Eastern Sweden Research Council [746981, 712291]; LinkopingUniversity-Region_Osterg_otland ALF [687681, 792291]
  • Aims Primary acute heart failure (AHF) is a common cause of hospitalization. AHF may also develop postoperatively (pAHF). The aim of this study was to assess the incidence, phenotypes, determinants and outcomes of pAHF following non-cardiac surgery.Methods and results A total of 9164 consecutive high-risk patients undergoing 11 262 non-cardiac inpatient surgeries were prospectively included. The incidence, phenotypes, determinants and outcome of pAHF, centrally adjudicated by independent cardiologists, were determined. The incidence of pAHF was 2.5% (95% confidence interval [CI] 2.2-2.8%); 51% of pAHF occurred in patients without known heart failure (de novo pAHF), and 49% in patients with chronic heart failure. Among patients with chronic heart failure, 10% developed pAHF, and among patients without a history of heart failure, 1.5% developed pAHF. Chronic heart failure, diabetes, urgent/emergent surgery, atrial fibrillation, cardiac troponin elevations above the 99th percentile, chronic obstructive pulmonary disease, anaemia, peripheral artery disease, coronary artery disease, and age, were independent predictors of pAHF in the logistic regression model. Patients with pAHF had significantly higher all-cause mortality (44% vs. 11%, p < 0.001) and AHF readmission (15% vs. 2%, p < 0.001) within 1 year than patients without pAHF. After Cox regression analysis, pAHF was an independent predictor of all-cause mortality (adjusted hazard ratio [aHR] 1.7 [95% CI 1.3-2.2]; p < 0.001) and AHF readmission (aHR 2.3 [95% CI 1.5-3.7]; p < 0.001). Findings were confirmed in an external validation cohort using a prospective multicentre cohort of 1250 patients (incidence of pAHF 2.4% [95% CI 1.6-3.3%]).Conclusions Postoperative AHF frequently developed following non-cardiac surgery, being de novo in half of cases, and associated with a very high mortality.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Puelacher, ChristianUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Chew, MichelleLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US(Swepub:liu)micch61 (författare)
  • Andersson, HenrikLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US(Swepub:liu)henan81 (författare)
  • Buse, Giovanna LuratiUniv Hosp Dusseldorf, Germany (författare)
  • Glarner, NoemiUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Mueller, DariaUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Cardozo, Francisco A. M.Univ Sao Paulo, Brazil (författare)
  • Burri-Winkler, KatrinUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Mork, ConstantinUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Wussler, DesireeUniv Basel, Switzerland; Univ Hosp Basel, Switzerland; Univ Basel, Switzerland (författare)
  • Shrestha, SamyutUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Heidelberger, IsabelleUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Fält, MikaelLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US(Swepub:liu)mikfa16 (författare)
  • Hidvegi, RekaUniv Basel, Switzerland; Univ Hosp Basel, Switzerland; Cantonal Hosp St Gallen, Switzerland (författare)
  • Bolliger, DanielUniv Basel, Switzerland (författare)
  • Lampart, AndreasUniv Basel, Switzerland (författare)
  • Steiner, Luzius A. A.Univ Basel, Switzerland; Univ Basel, Switzerland (författare)
  • Scharen, StefanUniv Hosp Basel, Switzerland (författare)
  • Kindler, ChristophUniv Basel, Switzerland (författare)
  • Gurke, LorenzUniv Basel, Switzerland (författare)
  • Rikli, DanielUniv Basel, Switzerland (författare)
  • Lardinois, Didier (författare)
  • Osswald, StefanUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Buser, AndreasUniv Basel, Switzerland (författare)
  • Caramelli, BrunoUniv Sao Paulo, Brazil (författare)
  • Mueller, ChristianUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (författare)
  • Univ Basel, Switzerland; Univ Hosp Basel, Switzerland; Univ Sao Paulo, BrazilUniv Basel, Switzerland; Univ Hosp Basel, Switzerland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Heart Failure: WILEY25:3, s. 347-3571388-98421879-0844

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