Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy

Furuhjelm, CatrinÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping (författare)

Maternal intake of omega-3 (-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy. Aim: To describe the effects of maternal -3 long-chain PUFA supplementation during pregnancy and lactation on the incidence of allergic disease in infancy. Methods: One hundred and forty-five pregnant women, affected by allergy themselves or having a husband or previous child with allergies, were included in a randomized placebo-controlled trial. Daily maternal supplementation with either 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo was given from the 25(th) gestational week to average 3-4 months of breastfeeding. Skin prick tests, detection of circulating specific immunoglobulin E (IgE) antibodies and clinical examinations of the infants were performed. Results: The period prevalence of food allergy was lower in the -3 group (1/52, 2%) compared to the placebo group (10/65, 15%, p andlt; 0.05) as well as the incidence of IgE-associated eczema (-3 group: 4/52, 8%; placebo group: 15/63, 24%, p andlt; 0.05). Conclusion: Maternal -3 fatty acid supplementation may decrease the risk of food allergy and IgE-associated eczema during the first year of life in infants with a family history of allergic disease.

Warstedt, KristinaLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)kriwa38 (författare)
Larsson, JohannaRyhov Hospital (författare)
Fredriksson, MatsLinköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet (författare)
Böttcher, MalinLinköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)malfa24 (författare)
Fälth-Magnusson, KarinÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)karfa12 (författare)
Duchén, KarelÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)kardu59 (författare)
Linköpings universitetPediatrik (creator_code:org_t)

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