The Role of Bowmans Layer in Corneal Regeneration after Phototherapeutic Keratectomy: A Prospective Study Using In Vivo Confocal Microscopy

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Lagali, NeilLinköpings universitet,Östergötlands Läns Landsting,Ögonkliniken US/LiM,Oftalmiatrik,Hälsouniversitetet (författare)

The Role of Bowmans Layer in Corneal Regeneration after Phototherapeutic Keratectomy : A Prospective Study Using In Vivo Confocal Microscopy

Artikel/kapitelEngelska2009

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Association for Research in Vision and Ophthalmology (ARVO),2009
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LIBRIS-ID:oai:DiVA.org:liu-20753
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20753URI
https://doi.org/10.1167/iovs.09-3781DOI

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Språk:engelska
Sammanfattning på:engelska

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Original Publication: Neil Lagali, Johan Germundsson and Per Fagerholm, The Role of Bowmans Layer in Corneal Regeneration after Phototherapeutic Keratectomy: A Prospective Study Using In Vivo Confocal Microscopy, 2009, INVESTIGATIVE OPHTHALMOLOGY and VISUAL SCIENCE, (50), 9, 4192-4198. http://dx.doi.org/10.1167/iovs.09-3781 Copyright: Research in Vision and Opthalmology http://www.arvo.org/
PURPOSE. To examine the role of Bowmans layer (BL) on the nature of anterior corneal regeneration after excimer laser phototherapeutic keratectomy (PTK). METHODS. A cohort of 13 patients underwent PTK to remove either 7 mu m of BL for treatment of primary recurrent corneal erosions (RCE; six patients) or complete BL removal (15-mu m ablation) to treat RCE or poor vision secondary to map-dot-fingerprint (MDF) dystrophy (seven patients). Clinical examinations and laser-scanning in vivo confocal microscopy (IVCM) were conducted before surgery and at a mean of 4 and 8 months after surgery. RESULTS. Total BL removal resulted in a significant decline in subbasal nerve density at 4 months (P = 0.007) that barely recovered to preoperative levels at 8 months (P = 0.055). With BL partially present, subbasal nerve density did not significantly change from preoperative levels. Superficial, wing, and basal epithelial cell density recovered to preoperative levels within 4 months after PTK, regardless of the presence of BL. Subepithelial keratocytes, however, were more densely distributed in corneas without BL relative to those with a partial BL present (P = 0.005), and increased anterior keratocyte reflectivity was noted in all eyes without BL and in no eye with a partial BL present. CONCLUSIONS. Subbasal nerve regeneration is delayed and subepithelial keratocyte density and reflectivity remain elevated up to 10 months after total BL removal by PTK. The results provide initial evidence for a possible role of BL in facilitating rapid stromal wound healing and an associated recovery of anterior corneal transparency and the restoration of epithelial innervation after epithelial trauma.

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MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Germundsson, JohanLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)johge81 (författare)
Fagerholm, PerÖstergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM(Swepub:liu)perfa04 (författare)
Östergötlands Läns LandstingÖgonkliniken US/LiM (creator_code:org_t)

Sammanhörande titlar

Ingår i:INVESTIGATIVE OPHTHALMOLOGY and VISUAL SCIENCE: Association for Research in Vision and Ophthalmology (ARVO)50:9, s. 4192-41980146-0404
Ingår i:Investigative Opthalmology & Visual Science: Association for Research in Vision and Ophthalmology (ARVO)50:9, s. 4192-41981552-5783

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Av författaren/redakt...: Lagali, Neil; Germundsson, Joh ...; Fagerholm, Per

Artiklar i publikationen: INVESTIGATIVE OP ...; Investigative Op ...

Av lärosätet: Linköpings universitet

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