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Progesterone and no...
Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum
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- Rugarn, Olof (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Hammar, Mats, 1950- (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Theodorsson, Elvar, 1953- (författare)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Regulatory Peptides. - 0167-0115 .- 1873-1686. ; 101:1-3, s. 87-91
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats.Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT.Conclusion: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum.The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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