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Sökning: onr:"swepub:oai:DiVA.org:liu-36132" > Dietary insulin as ...

  • Tittanden, MDept of Viral Diseases and Immunology Helsinki, Finland (författare)

Dietary insulin as an immunogen and tolerogen

  • Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

  • Wiley,2006
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-36132
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-36132URI
  • https://doi.org/10.1111/j.1399-3038.2006.00447.xDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • We have shown that exposure to bovine insulin (BI) in cow's milk (CM) formula induces an insulin-specific immune response in infants. Here we studied the role of human insulin (HI) in breast milk as a modulator of the immune response to insulin. In a group of 128 children participating in the TRIGR pilot study, maternal breast milk samples were collected 3-7 days and/or 3 months after delivery. After exclusive breast-feeding, the children received either CM formula or casein hydrolysate during the first 6-8 months of life. Insulin concentration in breast milk and immunoglobulin G (IgG) antibodies to BI in plasma samples were measured by EIA. The levels of insulin in breast milk samples were higher in mothers affected by type 1 diabetes than in non-diabetic mothers (p = 0.007 and p < 0.001). The concentration of insulin in breast milk correlated inversely with the plasma levels of IgG antibodies to BI at 6 months of age in children who received CM formula (r = -0.39, p = 0.013), and at 12 months of age in all children (r = -0.25, p = 0.029). The levels of breast milk insulin were higher in the mothers of nine children who developed beta-cell autoimmunity when compared with autoantibody-negative children (p = 0.030), this holds true also when only children of diabetic mothers were included (p = 0.045). BI in CM induces higher levels of IgG to insulin in infants than does HI in breast-fed children. Instead, HI in breast milk seems to be tolerogenic and may downregulate the IgG response to dietary BI. However, our results in infants who developed beta-cell autoimmunity suggest that in this subgroup of children breast milk insulin does not promote tolerance. © 2006 The Authors.

Ämnesord och genrebeteckningar

  • breast milk
  • insulin
  • insulin antibodies
  • type 1 diabetes
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Paronen, JohannaDept of Viral Diseases and Immunology Helsinki, Finland (författare)
  • Savilahti, ErkkiHospital for Children And Adolescents Helsinki, Finland (författare)
  • Virtanen, SuviDept of Epidemilogy and Health Promotion National Public Health Inst, Finland (författare)
  • Ilonen, JormaDept of Clinical Microbiology University of Kuopio, Finland (författare)
  • Knip, MikaelHospital for Children and Adolescents University of Helsinki, Finland (författare)
  • Åkerblom, HansHospital for chldren and Adolescents University of Helsinki, Finland (författare)
  • Vaarala, Outi,1962-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping(Swepub:liu)outva41 (författare)
  • Dept of Viral Diseases and Immunology Helsinki, FinlandHospital for Children And Adolescents Helsinki, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Allergy and Immunology: Wiley17:7, s. 538-5430905-61571399-3038

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