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A systematic survey...
A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease
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Teml, Alexander (författare)
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Schwab, Matthias (författare)
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Hommes, Daan W (författare)
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- Almer, Sven, 1953- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Gastroenterologi och hepatologi,Endokrin- och magtarmmedicinska kliniken US
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Lukas, Milan (författare)
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Feichtenschlager, Thomas (författare)
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Florin, Timothy (författare)
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Seiderer, Julia (författare)
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Petritsch, Wolfgang (författare)
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Bokemeyer, Bernd (författare)
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Kreisel, Wolfgang (författare)
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Herrlinger, Klaus R (författare)
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Knoflach, Peter (författare)
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Bonaz, Bruno (författare)
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Klugmann, Thomas (författare)
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Herfarth, Hans (författare)
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Pedarnig, Nikolaus (författare)
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Reinisch, Walter (författare)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2007
- 2007
- Engelska.
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Ingår i: Wiener Klinische Wochenschrift. - : Springer Science and Business Media LLC. - 0043-5325 .- 1613-7671. ; 119:17-18, s. 519-526
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVE: Drug-induced liver injury was recently reported as a major complication leading to hepatic nodular regenerative hyperplasia (NRH) in patients with inflammatory bowel disease (IBD) and 6-thioguanine (6-TG) therapy. The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey. METHODS: Clinical and laboratory data, imaging techniques (sonography, CT, MRI) and histology of liver biopsies were surveyed in IBD patients treated with 6-TG. The decision on whether liver imaging and/or liver biopsy were performed was exclusively at the discretion of the investigator. RESULTS: 6-TG use was fully documented in 296 patients (median treatment duration 56 weeks, range < 1-207). Laboratory signs of drug-induced liver injury were found in 43 patients (14.5%). Liver imaging revealed pathologic results in 68/176 patients (38.6%). Liver biopsy was performed in a subset of 60 patients, using silver-reticulin staining (n = 59), NRH was considered in 16 patients (27.1%). Age was the only independent, albeit weak, risk factor for development of NRH. CONCLUSION: This large online survey confirms the strong association between 6-TG treatment and the significant risk of development of NRH in patients with IBD. The definitive diagnosis of NRH depends solely upon liver biopsy. © 2007 Springer-Verlag.
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Teml, Alexander
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Schwab, Matthias
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Hommes, Daan W
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Almer, Sven, 195 ...
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Lukas, Milan
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Feichtenschlager ...
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visa fler...
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Florin, Timothy
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Seiderer, Julia
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Petritsch, Wolfg ...
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Bokemeyer, Bernd
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Kreisel, Wolfgan ...
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Herrlinger, Klau ...
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Knoflach, Peter
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Bonaz, Bruno
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Klugmann, Thomas
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Herfarth, Hans
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Pedarnig, Nikola ...
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Reinisch, Walter
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visa färre...
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Wiener Klinische ...
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Linköpings universitet