Sökning: onr:"swepub:oai:DiVA.org:liu-40004" > Association of NFKB...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03679naa a2200397 4500 | |
001 | oai:DiVA.org:liu-40004 | |
003 | SwePub | |
008 | 091010s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-400042 URI |
024 | 7 | a https://doi.org/10.1080/003655206008808562 DOI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gao, Jingfang,d 1966-u Linköpings universitet,Hälsouniversitetet,Onkologi4 aut0 (Swepub:liu)jinga59 |
245 | 1 0 | a Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations |
264 | c 2009-07-08 | |
264 | 1 | b Informa UK Limited,c 2007 |
338 | a print2 rdacarrier | |
520 | a Objective. The inhibitory proteins, IκBs, regulate the activity of nuclear factor kappa-beta (NF-κB), which is implicated in tumorigenesis by regulating expression of a variety of genes involved in cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants in the genes encoding IκBs may be involved in cancer development through the activation of NF-κB. The objective of this study was to investigate the susceptibility of an A to G variation (rs696) in the 3′ UTR of NFKBIA (encoding IκBα) to colorectal cancer (CRC) and the association of this polymorphism with clinicopathologic variables in CRC patients. Material and methods. A case-control study was carried out on a Swedish (155 CRCs, 438 controls) and a Chinese population (199 CRCs, 577 controls). The genotype of NFKBIA was determined by PCR-restriction fragment length polymorphism. Results. The frequency of the AG genotype was increased in the Chinese patients ≥50 years of age compared with the Chinese controls (odds ratio (OR) = 3.06, 95% confidence interval (CI) = 1.55-6.02, p=0.001), even when adjusted for age (OR = 3.20, 95% CI = 1.61-6.38, p=0.001). The GG genotype of NFKBIA was related to a poorer survival rate in the Swedish patients, independent of gender, age, tumour location, Dukes' stage and differentiation (hazard ratio = 3.10, 95% Cl = 1.28-7.60, p=0.01). Conclusions. Chinese individuals ≥50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients. © 2007 Taylor & Francis. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Pfeifer, Daniella,d 1981-u Linköpings universitet,Hälsouniversitetet,Onkologi4 aut0 (Swepub:liu)danpf07 |
700 | 1 | a He, Lu-Jun4 aut |
700 | 1 | a Qiao, Fang4 aut |
700 | 1 | a Zhang, Zhiyong4 aut |
700 | 1 | a Arbman, Gunnar,d 1949-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)gunar63 |
700 | 1 | a Wang, Zhen-Lei4 aut |
700 | 1 | a Jia, Cun-Rong4 aut |
700 | 1 | a Carstensen, John,d 1953-u Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle4 aut0 (Swepub:liu)johca98 |
700 | 1 | a Sun, Xiao-Feng,d 1959-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US4 aut0 (Swepub:liu)xiasu45 |
710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
773 | 0 | t Scandinavian Journal of Gastroenterologyd : Informa UK Limitedg 42:3, s. 345-350q 42:3<345-350x 0036-5521x 1502-7708 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40004 |
856 | 4 8 | u https://doi.org/10.1080/00365520600880856 |
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