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Chronic amitriptyli...
Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats
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- Johansson, Inga-Maj (författare)
- Department of Medicine, Umeå University Hospital, S-901 85 Umeå, Sweden
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- Bjartmar, Lisa, 1966- (författare)
- Linköpings universitet,Geriatrik,Hälsouniversitetet
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- Marcusson, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Geriatrik,Hälsouniversitetet,Geriatriska kliniken
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- Ross, Svante (författare)
- Astra Arcus, Södertälje, Sweden
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- Seckl, Jonathan (författare)
- Department of Medicine, Western General Hospital, Edinburgh, Scotland, UK
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- Olsson, Tommy (författare)
- Department of Medicine, Umeå University Hospital, S-901 85 Umeå, Sweden
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(creator_code:org_t)
- Elsevier Science B.V. 1998
- 1998
- Engelska.
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Ingår i: Brain Research. Molecular Brain Research. - : Elsevier Science B.V.. - 0169-328X .- 1872-6941. ; 62:1, s. 92-95
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions. There was no change in the NGFI-B mRNA expression. Thus, NGFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs.
Nyckelord
- NGFI-A
- glucocorticoid receptor
- antidepressant
- hippocampus
- transcription factor
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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