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Characteristics and...
Characteristics and long-term outcome of patients with autoimmune hepatitis related to the initial treatment response
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- Werner, Marten (författare)
- Umeå universitet,Medicin,Umeå University Hospital
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- Wallerstedt, Sven (författare)
- Sahlgrens University Hospital
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- Lindgren, Stefan (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Bjornsson, Einar (författare)
- Sahlgrens University Hospital
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- Bergquist, Annika (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Prytz, Hanne (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital
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- Sandberg-Gertzen, Hanna (författare)
- Örebro University Hospital
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Sangfelt, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Weiland, Ola (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups,Malmö University Hospital
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- Danielsson, Åke (författare)
- Umeå universitet,Medicin,Umeå University Hospital
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(creator_code:org_t)
- 2010-01-18
- 2010
- Engelska.
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Ingår i: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - : Taylor and Francis. - 0036-5521 .- 1502-7708. ; 45:4, s. 457-467
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objectives. Autoimmune hepatitis (AIH) is a liver disease which, if untreated, may lead to liver cirrhosis and hepatic failure. Limited data exist regarding factors predicting the long-term outcome. The aims of this study were to investigate symptoms at presentation, prognostic features, management and treatment in relation to long-term outcome of AIH. Material and methods. A cohort of 473 Swedish patients with AIH was characterized regarding initial symptoms and signs, factors predicting death and future need for liver transplantation. Survival and causes of death were retrieved from Swedish national registers. Results. At diagnosis, fatigue was a predominant symptom (69%), 47% of the patients were jaundiced and 30% had liver cirrhosis. Another 10% developed cirrhosis during follow-up. Markedly elevated alanine aminotransferase levels at presentation were correlated with a better outcome. A high international normalized ratio (INR) at diagnosis was the only risk factor predicting a need for later liver transplantation. Histological cirrhosis, decompensation and non-response to initial treatment were all factors that correlated with a worse outcome. Overall life expectancy was generally favourable. However, most deaths were liver-related, e.g. liver failure, shock and gastrointestinal bleeding. Conclusions. Cirrhosis at diagnosis, a non-response to initial immune-suppressive treatment or elevated INR values were associated with worse outcome and a need for later liver transplantation. In contrast, an acute hepatitis-like onset with intact synthetic capacity indicated a good response to treatment and favourable long-term prognosis. Lifetime maintenance therapy is most often required.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Autoimmune hepatitis
- azathioprine
- cirrhosis
- follow-up
- treatment
- MEDICINE
- MEDICIN
- follow-up
- cirrhosis
- Autoimmune hepatitis
- azathioprine
- treatment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Werner, Marten
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Wallerstedt, Sve ...
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Lindgren, Stefan
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Almer, Sven
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Bjornsson, Einar
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Bergquist, Annik ...
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visa fler...
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Prytz, Hanne
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Sandberg-Gertzen ...
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Hultcrantz, Rolf
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Sangfelt, Per
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Weiland, Ola
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Ohlsson, Bodil
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Danielsson, Åke
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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SCANDINAVIAN JOU ...
- Av lärosätet
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Linköpings universitet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet
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Uppsala universitet