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Asymptomatic Norovi...
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Bucardo, FilemonUniversity of Leon
(författare)
Asymptomatic Norovirus Infections in Nicaraguan Children and its Association With Viral Properties and Histo-blood Group Antigens
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Williams and Wilkins,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-60232
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60232URI
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https://doi.org/10.1097/INF.0b013e3181ed9f2fDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121306107URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: It has been previously reported that histo-blood group antigens (HBGAs) and particularly secretor status provides protection against symptomatic norovirus infection, but it remains unclear to what extent this includes asymptomatic infections in children. Methods: To explore whether HBGAs or certain viral genotypes are associated with asymptomatic norovirus infections in a pediatric population in Nicaragua, we investigated 163 children andlt;= 5 years of age, without a recent history of diarrhea (andlt;= 10 days). Results: Asymptomatic norovirus infections were observed in 11.7% (19/163), with children andlt;= 6 months of age being most frequently infected (16%). Of the 19 norovirus-positive children, 4 (21%) and 10 (53%) were infected with genogroups GI and GII, respectively, and 4 children (21%) were infected with viruses of both genogroups. Most children had andgt;= 10(6) viral genomes per gram of feces. Nucleotide sequence analysis (15/19) revealed uncommon genotypes, such as, GII. 7 (n = 5) and GII. 2 (n = 3). An interesting observation was the low frequency of norovirus GII. 4 strains among the asymptomatic children. AB blood type, Lewis a (Lea(a+b-)) phenotype and nonsecretor genotype (se(428)se(428)) were not found among the asymptomatic children, but they occurred in population controls. Conclusions: Frequency of asymptomatic norovirus infections was similar to that observed in symptomatic children from Nicaragua. Norovirus GII. 2 and GII. 7 were frequently detected but the globally dominating GII. 4 was infrequent. Host genetic factors previously observed to be associated with protection against symptomatic norovirus infection were not found in this study.
Ämnesord och genrebeteckningar
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norovirus
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asymptomatic
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host genetic factors
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nordgren, JohanLinköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet(Swepub:liu)johno12
(författare)
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Paniagua, MargaritaUniversity of Leon
(författare)
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Mollby, RolandKarolinska Institutet,Karolinska Institute
(författare)
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Svensson, LennartLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)lensv66
(författare)
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Carlsson, B
(författare)
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Kindberg, E
(författare)
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University of LeonMedicinsk mikrobiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PEDIATRIC INFECTIOUS DISEASE JOURNAL: Williams and Wilkins29:10, s. 934-9390891-36681532-0987
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