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In vitro Lymphocyte...
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Cederbrant, KarinLinköpings universitet,Kirurgi,Patologi,Hälsouniversitetet
(författare)
In vitro Lymphocyte Proliferation as Compared to Patch Test Using Gold, Palladium and Nickel
- Artikel/kapitelEngelska1997
Förlag, utgivningsår, omfång ...
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2009-09-04
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S. Karger AG,1997
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-79573
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79573URI
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https://doi.org/10.1159/000237456DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: A conventional lymphocyte transformation test (LTT) was compared to the commercially available MELISA® (memory lymphocyte immuno-stimulation assay), a lymphoproliferative assay that has been suggested to be a valuable instrument for the diagnosis of metal allergy. Sensitivity and specificity of the two assays were calculated using a patch test as a reference method.Methods: 34 patients were patch-tested for gold sodium thiosulfate, palladium chloride and nickel sulfate, and the lymphocyte proliferation to these metals was tested in vitro using mononuclear cells from peripheral blood.Results: No significant differences regarding sensitivity and specificity were found between MELISA and conventional LTT. The sensitivity varied between 55 and 95% and the specificity between 17 and 79%.Conclusions: The low specificity of the two in vitro assays suggests that they are not useful for diagnosis of contact allergy to the metals gold, palladium and nickel, since a large number of false-positive results will be obtained.
Ämnesord och genrebeteckningar
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Lymphocytes human
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Skin test
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Metals
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hultman, PerLinköpings universitet,Patologi,Hälsouniversitetet(Swepub:liu)perhu66
(författare)
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Marcusson, Jan A.Department of Dermatology, Huddinge Hospital, Huddinge
(författare)
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Tibbling, LitaLinköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
(författare)
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Linköpings universitetKirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Archives of Allergy and Immunology: S. Karger AG112:3, s. 212-2171018-24381423-0097
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