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Can ELISPOT Be Appl...
Can ELISPOT Be Applied to A Clinical Setting as A Diagnostic Utility for Neuroborreliosis?
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- Nordberg, Marika (författare)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Forsberg, Pia (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Nyman, Dag (författare)
- The Åland Borrelia Group, Åland, 22100 Mariehamn, Åland, Finland
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- Skogman, Barbro H. (författare)
- Center for Clinical Research (CKF) Dalarna, 791 36 Falun, Sweden
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- Nyberg, Clara (författare)
- The Åland Borrelia Group, Åland, 22100 Mariehamn, Åland, Finland
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- Ernerudh, Jan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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- Eliasson, Ingvar (författare)
- Department of Laboratory Medicine, NÄL, 461 85 Trollhättan, Sweden
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- Ekerfelt, Christina (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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(creator_code:org_t)
- 2012-06-08
- 2012
- Engelska.
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Ingår i: Cells. - Basel, Switzerland : MDPI AG. - 2073-4409. ; 13:48, s. 153-167
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The aim of this prospective study was to investigate the diagnostic performance of Borrelia (Bb)-induced interferon (IFN)-γ secretion detected by ELISPOT modified to be feasible for clinical laboratories as a supplementary test to the laboratory diagnosis of Lyme neuroborreliosis (LNB) in an endemic setting. Between 2002 and 2004, patients with symptoms of suspected clinical LNB were included in a study conducted on the Åland islands in the Finnish archipelago, which is a hyper-endemic area for Lyme borreliosis (LB). Fourteen patients with confirmed LNB and 103 patients with non-LNB were included, and the numbers of spontaneous and Bb-induced IFN-γ-secreting cells were assayed by the ELISPOT test. The ELISPOT assay showed a weak diagnostic performance with a sensitivity of 36% and a specificity of 82%. The findings in this study show that this ELISPOT-assay modified to be feasible in clinical routine laboratories is not useful as a supplementary diagnostic tool in the laboratory diagnosis of patients with clinically suspected LNB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- Borrelia burgdorferi; neuroborreliosis; ELISPOT; cerebrospinal fluid; diagnostic test; sensitivity; specificity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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