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LTBP-2 confers plei...
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Chen, HanHong Kong University of Science and Technology, Peoples R China
(författare)
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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Elsevier,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-84878
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84878URI
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https://doi.org/10.1016/j.canlet.2012.06.005DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125300182URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||
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This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.
Ämnesord och genrebeteckningar
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Latent transforming growth factor beta binding protein 2 (LTBP-2)
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Nasopharyngeal carcinoma (NPC)
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Anti-angiogenesis
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Tumor suppression
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Tumor cell dormancy
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Metastatic growth
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TECHNOLOGY
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TEKNIKVETENSKAP
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mun Yee Ko, JosephineUniversity of Hong Kong, Peoples R China
(författare)
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Chun Lam Wong, VictorUniversity of Hong Kong, Peoples R China
(författare)
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Hyytiainen, MarkoUniversity of Helsinki, Finland University of Helsinki, Finland
(författare)
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Keski-Oja, JormaUniversity of Helsinki, Finland University of Helsinki, Finland
(författare)
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Chua, DanielUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China Hong Kong Sanat and Hospital, Peoples R China
(författare)
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Nicholls, John MUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(författare)
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Man Fung Cheung, FlorenceUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
(författare)
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Wing Mui Lee, AnneUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
(författare)
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Lai-Wan Kwong, DoraUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(författare)
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Man Chiu, PuiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(författare)
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Zabarovsky, Eugene RLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
(författare)
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Wah Tsao, SaiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(författare)
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Tao, QianChinese University of Hong Kong, Peoples R China
(författare)
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Kan, RebeccaUniversity of Hong Kong, Peoples R China
(författare)
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Ho Kin Chan, StephenUniversity of Hong Kong, Peoples R China
(författare)
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Stanbridge, Eric JUniversity of Calif Irvine, CA 92697 USA
(författare)
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Li Lung, MariaUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(författare)
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Hong Kong University of Science and Technology, Peoples R ChinaUniversity of Hong Kong, Peoples R China
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer Letters: Elsevier325:1, s. 89-980304-38351872-7980
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Chen, Han
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Mun Yee Ko, Jose ...
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Chun Lam Wong, V ...
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Hyytiainen, Mark ...
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Keski-Oja, Jorma
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Chua, Daniel
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visa fler...
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Nicholls, John M
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Man Fung Cheung, ...
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Wing Mui Lee, An ...
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Lai-Wan Kwong, D ...
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Man Chiu, Pui
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Zabarovsky, Euge ...
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Wah Tsao, Sai
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Tao, Qian
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Kan, Rebecca
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Ho Kin Chan, Ste ...
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Stanbridge, Eric ...
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Li Lung, Maria
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visa färre...
- Artiklar i publikationen
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Cancer Letters
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet