Sökning: onr:"swepub:oai:DiVA.org:liu-96994" > Bortezomib consolid...
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001 | oai:DiVA.org:liu-96994 | |
003 | SwePub | |
008 | 130902s2013 | |||||||||||000 ||eng| | |
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009 | oai:DiVA.org:umu-79913 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-969942 URI |
024 | 7 | a https://doi.org/10.1182/blood-2012-11-4645032 DOI |
024 | 7 | a https://lup.lub.lu.se/record/40432012 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230332 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1271469492 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-799132 URI |
040 | a (SwePub)liud (SwePub)lud (SwePub)uud (SwePub)kid (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mellqvist, Ulf-Henriku Sahlgrens University Hospital, Sweden4 aut |
245 | 1 0 | a Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial |
264 | 1 | b American Society of Hematology,c 2013 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Johnson Johnson||Nordic Cancer Union||Boras foundation for cancer research|| | |
520 | a The Nordic Myeloma Study Group conducted an open randomized trial to compare bortezomib as consolidation therapy given after high-dose therapy and autologous stem cell transplantation (ASCT) with no consolidation in bortezomib-naive patients with newly diagnosed multiple myeloma. Overall, 370 patients were centrally randomly assigned 3 months after ASCT to receive 20 doses of bortezomib given during 21 weeks or no consolidation. The hypothesis was that consolidation therapy would prolong progression-free survival (PFS). The PFS after randomization was 27 months for the bortezomib group compared with 20 months for the control group (P = .05). Fifty-one of 90 patients in the treatment group compared with 32 of 90 controls improved their response after randomization (P = .007). No difference in overall survival was seen. Fatigue was reported more commonly by the bortezomib-treated patients in self-reported quality-of-life (QOL) questionnaires, whereas no other major differences in QOL were recorded between the groups. Consolidation therapy seemed to be beneficial for patients not achieving at least a very good partial response (VGPR) but not for patients in the andgt;= VGPR category at randomization. Consolidation with bortezomib after ASCT in bortezomib-naive patients improves PFS without interfering with QOL. This trial was registered at www.clinicaltrials.gov as #NCT00417911. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Gimsing, Peteru Rigshosp, Denmark4 aut |
700 | 1 | a Hjertner, Oyvindu Norwegian University of Science and Technology, Norway4 aut |
700 | 1 | a Lenhoff, Stigu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden4 aut0 (Swepub:lu)med-slf |
700 | 1 | a Laane, Edwardu North Estonian Regional Hospital, Estonia4 aut |
700 | 1 | a Remes, Kariu Turku University, Finland4 aut |
700 | 1 | a Steingrimsdottir, Hlifu Landspitali University Hospital, Iceland4 aut |
700 | 1 | a Abildgaard, Nielsu Odense University Hospital, Denmark4 aut |
700 | 1 | a Ahlberg, Luciau Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US4 aut0 (Swepub:liu)lucah64 |
700 | 1 | a Blimark, Cecilieu Sahlgrens University Hospital, Sweden4 aut |
700 | 1 | a Dahl, Inger Marieu University of North Norway, Norway4 aut |
700 | 1 | a Forsberg, Karinu Umeå universitet,Patologi,Norrlands University Hospital, Sweden4 aut0 (Swepub:umu)nonkin02 |
700 | 1 | a Gedde-Dahl, Tobiasu Oslo University Hospital, Norway4 aut |
700 | 1 | a Gregersen, Henriku Aalborg Hospital, Denmark4 aut |
700 | 1 | a Gruber, Astridu Karolinska Institute, Sweden4 aut |
700 | 1 | a Guldbrandsen, Ninau Oslo University Hospital, Norway4 aut |
700 | 1 | a Haukas, Einaru Stavanger University Hospital, Norway4 aut |
700 | 1 | a Carlson, Kristinau Uppsala universitet,Hematologi,Akad University Hospital, Sweden4 aut0 (Swepub:uu)krica965 |
700 | 1 | a Kvam, Ann Kristinu Oslo University Hospital, Norway4 aut |
700 | 1 | a Nahi, Harethu Karolinska Institutet,Karolinska Institute, Sweden4 aut |
700 | 1 | a Lindas, Roaldu Haukeland Hospital, Norway4 aut |
700 | 1 | a Frost Andersen, Nielsu Aarhus University Hospital, Denmark4 aut |
700 | 1 | a Turesson, Ingemaru Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden4 aut0 (Swepub:lu)medf-itu |
700 | 1 | a Waage, Andersu Norwegian University of Science and Technology, Norway4 aut |
700 | 1 | a Westin, Janu Sahlgrens University Hospital, Sweden4 aut |
710 | 2 | a Sahlgrens University Hospital, Swedenb Rigshosp, Denmark4 org |
773 | 0 | t Bloodd : American Society of Hematologyg 121:23, s. 4647-4654q 121:23<4647-4654x 0006-4971x 1528-0020 |
856 | 4 | u https://ashpublications.org/blood/article-pdf/121/23/4647/1366249/4647.pdf |
856 | 4 | u http://dx.doi.org/10.1182/blood-2012-11-464503x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96994 |
856 | 4 8 | u https://doi.org/10.1182/blood-2012-11-464503 |
856 | 4 8 | u https://lup.lub.lu.se/record/4043201 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223033 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127146949 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79913 |
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