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Nanolithographic Fa...
Nanolithographic Fabrication Technologies for Network-Based Biocomputation Devices
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- Meinecke, Christoph R. (författare)
- Tech Univ Chemnitz, Germany;Fraunhofer Inst Elect Nano Syst ENAS, Germany,Fraunhofer Institute for Electronic Nanosystems (ENAS),Chemnitz University of Technology
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- Heldt, Georg (författare)
- Fraunhofer Inst Elect Nano Syst ENAS, Germany,Fraunhofer Institute for Electronic Nanosystems (ENAS)
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- Blaudeck, Thomas (författare)
- Tech Univ Chemnitz, Germany;Fraunhofer Inst Elect Nano Syst ENAS, Germany,Fraunhofer Institute for Electronic Nanosystems (ENAS),Chemnitz University of Technology
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- Lindberg, Frida W. (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH
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- van Delft, Falco C. M. J. M. (författare)
- Mol Sense Ltd, UK;Nanovalk, Netherlands,Molecular Sense Ltd.
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- Rahman, Mohammad Ashikur (författare)
- Linnaeus University,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),KTH Royal instute of technology, Sweden
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- Salhotra, Aseem (författare)
- Linnaeus University,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB)
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- Månsson, Alf (författare)
- Linnaeus University,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB)
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- Linke, Heiner (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,Other operations, LTH,Faculty of Engineering, LTH,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas
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- Korten, Till (författare)
- Tech Univ Dresden, Germany,Dresden University of Technology
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- Diez, Stefan (författare)
- Tech Univ Dresden, Germany;Max Planck Inst Mol Cell Biol & Genet, Germany,Max Planck Institute of Molecular Cell Biology and Genetics,Dresden University of Technology
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- Reuter, Danny (författare)
- Tech Univ Chemnitz, Germany;Fraunhofer Inst Elect Nano Syst ENAS, Germany,Chemnitz University of Technology,Fraunhofer Institute for Electronic Nanosystems (ENAS)
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- Schulz, Stefan E. (författare)
- Tech Univ Chemnitz, Germany;Fraunhofer Inst Elect Nano Syst ENAS, Germany,Chemnitz University of Technology,Fraunhofer Institute for Electronic Nanosystems (ENAS)
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(creator_code:org_t)
- 2023-01-24
- 2023
- Engelska.
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Ingår i: Materials. - : MDPI. - 1996-1944. ; 16:3
- Relaterad länk:
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https://doi.org/10.3...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic channel networks (NBC networks) using electron-beam lithography as the central method. To confirm the functionality of these NBC networks, we solve an instance of a classical non-deterministic-polynomial-time complete ("NP-complete") problem, the subset-sum problem. The propagation of cytoskeletal filaments, e.g., molecular motor-propelled microtubules or actin filaments, relies on a combination of physical and chemical guiding along the channels of an NBC network. Therefore, the nanofabricated channels have to fulfill specific requirements with respect to the biochemical treatment as well as the geometrical confienement, with walls surrounding the floors where functional molecular motors attach. We show how the material stack used for the NBC network can be optimized so that the motor-proteins attach themselves in functional form only to the floor of the channels. Further optimizations in the nanolithographic fabrication processes greatly improve the smoothness of the channel walls and floors, while optimizations in motor-protein expression and purification improve the activity of the motor proteins, and therefore, the motility of the filaments. Together, these optimizations provide us with the opportunity to increase the reliability of our NBC devices. In the future, we expect that these nanolithographic fabrication technologies will enable production of large-scale NBC networks intended to solve substantially larger combinatorial problems that are currently outside the capabilities of conventional software-based solvers.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Nyckelord
- nanotechnology
- electron-beam lithography
- network-based biocomputation
- microfluidics
- molecular motors
- Chemistry
- Kemi
- electron-beam lithography
- microfluidics
- molecular motors
- nanotechnology
- network-based biocomputation
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- Av författaren/redakt...
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Meinecke, Christ ...
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Heldt, Georg
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Blaudeck, Thomas
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Lindberg, Frida ...
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van Delft, Falco ...
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Rahman, Mohammad ...
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visa fler...
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Salhotra, Aseem
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Månsson, Alf
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Linke, Heiner
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Korten, Till
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Diez, Stefan
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Reuter, Danny
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Schulz, Stefan E ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Materialkemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Den kondenserade ...
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Materials
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Linnéuniversitetet
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Lunds universitet