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Risk factors for se...
Risk factors for severe asthma among adults with asthma
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- Backman, Helena (författare)
- Umeå universitet,Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Umeå university, Public Health and Clinical Medicine, section for Sustainable Health/the OLIN unit,Avdelningen för hållbar hälsa,Luleå University of Technology, Health Sciences, Luleå, Sweden
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- Stridsman, Caroline (författare)
- Umeå universitet,Avdelningen för medicin,Umeå University, Public Health and Clinical Medicine, section for Medicine/the OLIN unit, Luleå, Sweden
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- Jansson, Sven-Arne (författare)
- Umeå universitet,Avdelningen för hållbar hälsa,Umeå University, Public Health and Clinical Medicine, section for Sustainable Health/the OLIN unit, Luleå, Sweden
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Umeå university, Public Health and Clinical Medicine, section for Sustainable Health/the OLIN unit,Avdelningen för hållbar hälsa
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- Kankaanranta, Hannu (författare)
- Department of Respiratory Medicine, Seinäjoki Central Hospital, and Faculty of Medicine and Health Technology, University of Tampere, Seinäjoki, Finland
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- Lindberg, Anne (författare)
- Umeå universitet,Avdelningen för medicin,Umeå University, Public Health and Clinical Medicine, section for Medicine/the OLIN unit, Umeå, Sweden
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- Lundback, Bo (författare)
- Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Gothenburg, Sweden
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för medicin,Umeå University, Public Health and Clinical Medicine, section for Medicine/the OLIN unit, Luleå, Sweden
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(creator_code:org_t)
- 2020-10-28
- 2020
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 56:Suppl 64
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Severe asthma is a considerable challenge for patients, health care professionals and society, but there are few long-term studies on risk factors for severe asthma.Aim: To identify baseline risk factors of severe asthma in a longitudinal adult asthma cohort study.Methods: An adult asthma cohort was identified in 1986-2001 by clinical examinations of population samples within the OLIN studies in northern Sweden. The examinations included structured interviews, spirometry with reversibility testing, skin prick testing and metacholine challenge. The cohort was followed up in 2012-2014 when n=1006 participated (mean age 59y). Adjusted Risk Ratios (RR) for baseline factors as risk factors for GINA defined severe asthma (SA) at follow-up (n=51) were estimated by Poisson regression.Results: Older age, impaired lung function, increased reversibility and hyperreactivity, asthmatic wheeze, persistent wheeze, nighttime awakenings due to respiratory symptoms, and dyspnea were significant baseline risk factors for SA. Allergic sensitization, smoking, occupational groups or BMI did not predict SA. When adjusted for age, sex and smoking, post-bronchodilator FEV1/FVC<0.7, both present at baseline (RR 4.2, 95%CI 1.8-9.9) and developed during follow-up (2.9, 1.6-5.3), increased the risk. Also FEV1<80% at baseline associated with SA (2.9, 1.6-5.2). Triggers for respiratory symptoms at baseline such as tobacco smoke (2.1, 1.2-3.7) and physical activity (3.5, 1.5-81) associated with SA at follow-up, while pollen and furry animals did not.Conclusion: Among adults with asthma, impaired lung function, wheeze, dyspnea and nighttime awakenings due to respiratory symptoms are important long-term risk factors for severe asthma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- Adults
- Severe asthma
- Nursing
- Omvårdnad
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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