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Predictors of patie...
Predictors of patient-reported fatigue symptom severity in a nationwide multiple sclerosis cohort
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- Englund, Simon (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Kierkegaard, Marie (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
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- Burman, Joachim, 1974- (författare)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
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- Fink, Katharina (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Fogdell-Hahn, Anna (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Gunnarsson, Martin, 1973- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Fac Med & Hlth, Dept Neurol, Orebro, Sweden.
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- Hillert, Jan (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Langer-Gould, Annette (författare)
- Clinical and Translational Neuroscience, Southern California Permanente Medical Group, Kaiser Permanente, Pasadena, United States,Kaiser Permanente, Southern Calif Permanente Med Grp, Clin & Translat Neurosci, Pasadena, CA USA.
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- Lycke, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Nilsson, Petra (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Salzer, Jonatan (författare)
- Umeå University,Umeå universitet,Neurovetenskaper,Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden.
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- Svenningsson, Anders (författare)
- Karolinska Institutet,Danderyd Hosp Stockholm, Clin Sci, Stockholm, Sweden.,Danderyd Hospital
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- Mellergård, Johan (författare)
- Linköpings universitet,Linköping University,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
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- Olsson, Tomas (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Longinetti, Elisa (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden.
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- Frisell, Thomas (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Piehl, Fredrik (författare)
- Karolinska Institute,Karolinska Inst, Sweden
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Karolinska Institutet Karolinska Inst, Dept Clin Neurosci, Stockholm SE-17177, Sweden (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 70
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Fatigue is a debilitating symptom of multiple sclerosis (MS), but its relation to sociodemographic and disease-related characteristics has not been investigated in larger studies. The objectives of this study were to evaluate predictors of self-reported fatigue in a Swedish nationwide register-based MS cohort.METHODS: Using a repeated cross-sectional design, we included 2,165 persons with relapsing- remitting and secondary progressive MS with one or multiple Fatigue Scale for Motor and Cognitive Functions (FSMC) scores, which was modelled using multivariable linear regressions for multiple predictors.RESULTS: Only associations to expanded disability status scale (EDSS) and Symbol Digit Modalities Test (SDMT) were considered clinically meaningful among MS-associated characteristics in our main model; compared to mild disability (EDSS 0-2.5), those with severe disability (EDSS ≥6) scored 17.6 (95% CI 13.1-22.2) FSMC points higher, while the difference was 10.7 (95% CI 8.0-13.4) points for the highest and lowest quartiles of SDMT. Differences between highest and lowest quartiles of health-related quality of life (HRQoL) instruments were even greater and considered clinically meaningful; EuroQoL Visual Analogue Scale (EQ-VAS) 31.9 (95% CI 29.9-33.8), Multiple Sclerosis Impact Scale (MSIS-29) psychological component 35.6 (95% CI 33.8-37.4) and MSIS-29 physical component 45.5 (95% CI 43.7-47.4).CONCLUSION: Higher self-reported fatigue is associated with higher disability level and worse cognitive processing speed, while associations to other MS-associated characteristics including MS type, line of disease modifying therapy (DMT), MS duration, relapse and new cerebral lesions are weak. Furthermore, we found a strong correlation between high fatigue rating and lower ratings on health-related quality of life instruments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Cohort studies
- Comorbidity
- Fatigue
- Health-related quality of life
- Multiple sclerosis
- Quality of life
- Cohort studies
- Comorbidity
- Fatigue
- Health-related quality of life
- Multiple sclerosis
- Quality of life
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Englund, Simon
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Kierkegaard, Mar ...
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Burman, Joachim, ...
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Fink, Katharina
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Fogdell-Hahn, An ...
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Gunnarsson, Mart ...
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Hillert, Jan
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Langer-Gould, An ...
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Lycke, Jan, 1956
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Nilsson, Petra
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Salzer, Jonatan
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Svenningsson, An ...
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Mellergård, Joha ...
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Olsson, Tomas
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Longinetti, Elis ...
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Frisell, Thomas
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Piehl, Fredrik
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Multiple Scleros ...
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Karolinska Institutet
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Uppsala universitet
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Lunds universitet
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Linköpings universitet
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Göteborgs universitet
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