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Associations between various markers of intestinal barrier and immune function after a high-intensity exercise challenge
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- Roca Rubio, Maria Fernanda, 1989- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research CentreNutrition-Gut-Brain Interactions Research Centre
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- Folkesson, Mattias, 1972- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Kremp, Carolin (författare)
- School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
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- Evertsson, Niklas (författare)
- Nutrition-Gut-Brain Interactions Research Centre
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- Repsilber, Dirk, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Eriksson, Ulrika, 1972- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment (MTM) Research Centre
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- Ganda Mall, John Peter, 1988- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Kadi, Fawzi, 1970- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Physiological Reports. - : John Wiley & Sons. - 2051-817X. ; 12:10
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Strenuous exercise can result in disruption of intestinal barrier function and occurrence of gastrointestinal symptoms. The aim of this exploratory study was to elucidate systemic effects of increased intestinal permeability after high-intensity exercise. Forty-one endurance-trained subjects performed a 60-min treadmill run at 80% VO2max. Small intestinal permeability was measured as urinary excretion ratio of lactulose/rhamnose (L/R). Blood, saliva and feces were analyzed for gut barrier and immune-related biomarkers. The exercise challenge increased several markers of intestinal barrier disruption, immune function and oxidative stress. We found a negative correlation between L/R ratio and uric acid (r = -0.480), as well as a positive correlation between the L/R ratio and fecal chromogranin A in male participants (r = 0.555). No significant correlations were found between any of the markers and gastrointestinal symptoms, however, perceived exertion correlated with the combination of IL-6, IL-10 and salivary cortisol (r = 0.492). The lack of correlation between intestinal permeability and gastrointestinal symptoms could be due to minor symptoms experienced in lab settings compared to real-life competitions. The correlation between L/R ratio and uric acid might imply a barrier-protective effect of uric acid, and inflammatory processes due to strenuous exercise seem to play an important role regarding physical exhaustion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Gastrointestinal symptoms
- high‐intensity exercise
- intestinal barrier function
- intestinal permeability
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Roca Rubio, Mari ...
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Folkesson, Matti ...
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Kremp, Carolin
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Evertsson, Nikla ...
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Repsilber, Dirk, ...
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Eriksson, Ulrika ...
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visa fler...
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Ganda Mall, John ...
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Kadi, Fawzi, 197 ...
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Brummer, Robert ...
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König, Julia, 19 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Physiological Re ...
- Av lärosätet
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Örebro universitet