Sökning: onr:"swepub:oai:DiVA.org:oru-11654" >
Transmission-depend...
-
Färnert, AnnaKarolinska Institutet
(författare)
Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
Chicago :University of Chicago Press,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-11654
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11654URI
-
https://doi.org/10.1086/605652DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:119282560URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Whether the number of concurrent clones in asymptomatic Plasmodium falciparum infections reflects the degree of host protection was investigated in children living in areas with different levels of transmission on the coast of Kenya. The number of concurrent clones was determined on the basis of polymorphism in msp2, which encodes the vaccine candidate antigen merozoite surface protein 2. In a low-transmission area, most children had monoclonal infections, and diversity did not predict a risk of clinical malaria. In an area of moderate transmission, asymptomatic infections with 2 clones were, compared with 1 clone, associated with an increased risk of subsequent malaria. In a comparative assessment in a high-transmission area in Tanzania, multiclonal infections conferred a reduced risk. The different nonlinear associations between the number of clones and malaria morbidity suggest that levels of tolerance to multiclonal infections are transmission dependent as a result of cumulative exposure to antigenically diverse P. falciparum infections.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Williams, Thomas N.
(författare)
-
Mwangi, Tabitha W.
(författare)
-
Ehlin, Anna
(författare)
-
Fegan, Greg
(författare)
-
Macharia, Alex
(författare)
-
Lowe, Brett S.
(författare)
-
Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy
(författare)
-
Marsh, Kevin
(författare)
-
Karolinska InstitutetHälsoakademin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Infectious DiseasesChicago : University of Chicago Press200:7, s. 1166-11750022-18991537-6613
Internetlänk
Hitta via bibliotek
Till lärosätets databas