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Total adiponectin d...
Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study
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- Khalili, Payam (författare)
- Örebro universitet,Hälsoakademin
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- Flyvbjerg, A. (författare)
- Inst Clin, Med Res Labs, Aarhus Univ Hosp, Aarhus, Denmark
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- Frystyk, J. (författare)
- Inst Clin, Med Res Labs, Aarhus Univ Hosp, Aarhus, Denmark
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- Lundin, F. (författare)
- Varmland Cty Res Council, Karlstad, Sweden
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- Jendle, Johan, 1963- (författare)
- Örebro universitet,Hälsoakademin
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Nilsson, Peter (författare)
- Lund University,Lunds universitet,Örebro universitet,Hälsoakademin,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Diabetes & Metabolism. - : Elsevier BV. - 1262-3636 .- 1878-1780. ; 36:2, s. 137-143
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model.Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P<0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes.Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adiponectin
- Cardiovascular events
- Coronary events
- Glucose metabolism
- Stroke
- Prospective study
- Long-term
- Medicine
- Medicin
- metabolism
- Glucose
- Coronary events
- Adiponectin
- Cardiovascular events
- Stroke
- Prospective study
- Long-term
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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