Sökning: onr:"swepub:oai:DiVA.org:oru-38714" > Biomarker Discovery...
Fältnamn | Indikatorer | Metadata |
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000 | 06024naa a2200661 4500 | |
001 | oai:DiVA.org:oru-38714 | |
003 | SwePub | |
008 | 141118s2013 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-120037 | |
009 | oai:DiVA.org:uu-183399 | |
009 | oai:prod.swepub.kib.ki.se:125896989 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-387142 URI |
024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-12-11392 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1200372 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1833992 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1258969892 URI |
040 | a (SwePub)orud (SwePub)umud (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Botling, Johanu Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)johanbot |
245 | 1 0 | a Biomarker Discovery in Non-Small Cell Lung Cancer :b Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation |
264 | 1 | c 2013 |
338 | a print2 rdacarrier | |
500 | a Funding agencies are:Swedish Cancer Society Lions Cancer Foundation, Uppsala, Sweden German Research Foundation (DFG) RA 870/4-1, RA 870/5-1 Astra Zeneca Knut and Alice Wallenberg Foundation | |
520 | a Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap.Experimental Design: Here, we describe a novel single institute cohort, including 196 non-small lung cancers (NSCLC) with clinical information and long-term follow-up. Gene expression array data were used as a training set to screen for single genes with prognostic impact. The top 450 probe sets identified using a univariate Cox regression model (significance level P < 0.01) were tested in a meta-analysis including five publicly available independent lung cancer cohorts (n = 860).Results: The meta-analysis revealed 14 genes that were significantly associated with survival (P < 0.001) with a false discovery rate < 1%. The prognostic impact of one of these genes, the cell adhesion molecule 1 (CADM1), was confirmed by use of immunohistochemistry on tissue microarrays from 2 independent NSCLC cohorts, altogether including 617 NSCLC samples. Low CADM1 protein expression was significantly associated with shorter survival, with particular influence in the adenocarcinoma patient subgroup.Conclusions: Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics. Clin Cancer Res; 19(1); 194-204. (c) 2012 AACR. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Onkologi | |
653 | a Oncology | |
653 | a Pathology | |
700 | 1 | a Edlund, Karolinau Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)kaedl086 |
700 | 1 | a Lohr, Miriamu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut |
700 | 1 | a Hellwig, Birteu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut |
700 | 1 | a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)larsholmb |
700 | 1 | a Lambe, Mats G.u Karolinska Institutet4 aut |
700 | 1 | a Berglund, Andersu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)andbe182 |
700 | 1 | a Ekman, Simonu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)simoekma |
700 | 1 | a Bergqvist, Michaelu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)michberg |
700 | 1 | a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Pontén4 aut0 (Swepub:uu)fredpont |
700 | 1 | a König, Andréu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut |
700 | 1 | a Fernandes, Oswaldou Cardiothoracic Surgery, Örebro University Hospital, Örebro, Sweden4 aut |
700 | 1 | a Karlsson, Matsu Region Örebro län,Laboratory Medicine4 aut0 (Swepub:oru)mskn |
700 | 1 | a Helenius, Giselau Region Örebro län,Laboratory Medicine4 aut0 (Swepub:oru)ghs |
700 | 1 | a Karlsson, Christina,d 1968-u Örebro universitet, Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)ckn |
700 | 1 | a Rahnenfuehrer, Jörgu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut |
700 | 1 | a Hengstler, Jan G.u Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany4 aut |
700 | 1 | a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)patmi676 |
710 | 2 | a Uppsala universitetb Molekylär och morfologisk patologi4 org |
773 | 0 | t Clinical Cancer Researchg 19:1, s. 194-204q 19:1<194-204x 1078-0432x 1557-3265 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38714 |
856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-12-1139 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120037 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183399 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125896989 |
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