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Prognostic signific...
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Rueenauver, K.Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
(författare)
Prognostic significance of YWHAZ expression in localized prostate cancer
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-08-26
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Nature Publishing Group,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-40164
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-40164URI
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https://doi.org/10.1038/pcan.2014.32DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:Wilhelm Sander Foundation 2011.077.1Rudolf-Becker-FoundationGerman Research Foundation (Deutsche Forschungsgemeinschaft (DFG), Emmy-Noether-Program) PE1179/2-1Medical Faculty of the University of Bonn (BONFOR)Note: ToPCaP is a multinational research institute w. research locations in seven western countries
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BACKGROUND: Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were, used to assess the prognostic value of YWHAZ intensity.RESULTS: High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).CONCLUSIONS: Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Menon, R.Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
(författare)
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Svensson, Maria A.,1980-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine, University Hospital of Örebro, Örebro, Sweden; Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)mass
(författare)
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Carlsson, Jessica,1984-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)jccn
(författare)
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Vogel, W.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
(författare)
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Andrén, Ove,1963-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)oan
(författare)
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Nowak, M.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
(författare)
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Perner, S.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
(författare)
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Transdiciplinary Prostate Cancer Partership (ToPCaP), Sweden (Andrén, Carlsson, Svensson, on behalf of or aff. to), Group author
(författare)
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Region Örebro länInst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Prostate Cancer and Prostatic Diseases: Nature Publishing Group17:4, s. 310-3141365-78521476-5608
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