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Improved Muscle Mit...
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Fernström, Maria,1960-Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Clinical Medicine, Örebro University Hospital, Örebro, Sweden,CVRC,Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
(författare)
Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2015-10-15
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New York, USA :Springer,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-46417
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-46417URI
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https://doi.org/10.1007/s11695-015-1932-zDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-29648URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133762006URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4984URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:Swedish Transport AdministrationSwedish Nutrition FoundationStiftelsen SerafimerlasarettetStockholm County CouncilKarolinska Institutet
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Financial support was provided through grants from the Swedish Transport Administration, the Swedish Nutrition Foundation, the Swedish Research Council (no: 14244), Stiftelsen Serafimerlasarettet, and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet. The pedometers were generously provided by Abbott Scandinavia AB.
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Background: Weight loss resulting from low-calorie diets is often less than expected. We hypothesized that energy restriction would influence proton leakage and improve mitochondrial efficiency, leading to reduced energy expenditure, partly explaining the difficulties in weight loss maintenance.Methods: Eleven women with a median BMI of 38.5 kg/m(2) (q-range 37-40), and referred to gastric bypass surgery participated. Before surgery, and at 6 months of follow-up, muscle biopsies were collected from the vastus lateralis muscle. Mitochondria were isolated and analyzed for coupled (state 3) and uncoupled (state 4) respiration and mitochondrial capacity (P/O ratio).Results: At follow-up, the participants had a median BMI of 29.6 kg/m(2) (28.3-32.0). State 3 increased from 20.6 (17.9-28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0-49.0), p = 0.01, while state 4 increased from 2.8 (1.8-4.2) to 4.2 nmol O2/min/U CS (3.1-6.1), although not statistically significant. The P/O ratio increased from 2.7 (2.5-2.8) to 3.2 (3.0-3.4), p = 0.02, indicating improved mitochondrial efficiency.Conclusions: Six months after gastric bypass surgery, the mitochondrial capacity for coupled, i.e., ATP-generating, respiration increased, and the P/O ratio improved. Uncoupled respiration was not enhanced to the same extent. This could partly explain the decreased basal metabolism and the reduced inclination for weight loss during energy restriction.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bakkman, LindaDepartment of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Solna, Stockholm, Sweden
(författare)
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Loogna, PeterBariatric Center, Sophiahemmet, Stockholm, Sweden
(författare)
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Rooyackers, OlavKarolinska Institutet,Karolinska institutet
(författare)
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Svensson, Madeleine,1983-Högskolan i Halmstad,Centrum för forskning om välfärd, hälsa och idrott (CVHI),Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Solna, Stockholm, Sweden(Swepub:hh)madsve
(författare)
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Jakobsson, ToweDepartment of Anaesthesiology and Intensive Care, Karolinska Institutet, Huddinge, Stockholm, Sweden
(författare)
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Brandt, LenaKarolinska Institutet,Örebro University
(författare)
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Lagerros, Ylva TrolleKarolinska Institutet,Karolinska institutet
(författare)
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Örebro universitetInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Obesity SurgeryNew York, USA : Springer26:7, s. 1391-13970960-89231708-0428
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