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Perinatal risk fact...
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Brander, GustafKarolinska Institutet
(författare)
Perinatal risk factors in Tourette's and chronic tic disorders : a total population sibling comparison study
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2017-03-28
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Nature Publishing Group,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-57358
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57358URI
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https://doi.org/10.1038/mp.2017.31DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138214053URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:Karolinska Institutet PhD stipendDavid and Astrid Hagelen Foundation Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) 340-2013-5867 Indiana Clinical and Translational Sciences Institute: Pediatric Development Team Shire
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Adverse perinatal events may increase the risk of Tourette's and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed to prospectively investigate potential perinatal risk factors for TD/CTD, taking unmeasured factors shared between full siblings into account. A population-based birth cohort, consisting of all singletons born in Sweden in 1973-2003, was followed until December 2013. A total of 3 026 861 individuals were identified, 5597 of which had a registered TD/CTD diagnosis. We then studied differentially exposed full siblings from 947 942 families; of these, 3563 families included siblings that were discordant for TD/CTD. Perinatal data were collected from the Medical Birth Register and TD/CTD diagnoses were collected from the National Patient Register, using a previously validated algorithm. In the fully adjusted models, impaired fetal growth, preterm birth, breech presentation and cesarean section were associated with a higher risk of TD/CTD, largely independent from shared family confounders and measured covariates. Maternal smoking during pregnancy was associated with risk of TD/CTD in a dose-response manner but the association was no longer statistically significant in the sibling comparison models or after the exclusion of comorbid attention-deficit/hyperactivity disorder. A dose-response relationship between the number of adverse perinatal events and increased risk for TD/CTD was also observed, with hazard ratios ranging from 1.41 (95% confidence interval (CI): 1.33-1.50) for one event to 2.42 (95% CI: 1.65-3.53) for five or more events. These results pave the way for future gene by environment interaction and epigenetic studies in TD/CTD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rydell, MinaKarolinska Institutet
(författare)
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Kuja-Halkola, RalfKarolinska Institutet
(författare)
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Fernández de la Cruz, LorenaKarolinska Institutet
(författare)
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Lichtenstein, Paul S.Karolinska Institutet
(författare)
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Serlachius, EvaKarolinska Institutet
(författare)
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Rück, ChristianKarolinska Institutet
(författare)
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Almqvist, CatarinaKarolinska Institutet
(författare)
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D'Onofrio, Brian M.Karolinska Institutet
(författare)
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Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln
(författare)
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Mataix-Cols, DavidKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Psychiatry: Nature Publishing Group23:5, s. 1189-11971359-41841476-5578
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Brander, Gustaf
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Rydell, Mina
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Kuja-Halkola, Ra ...
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Fernández de la ...
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Lichtenstein, Pa ...
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Serlachius, Eva
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visa fler...
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Rück, Christian
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Almqvist, Catari ...
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D'Onofrio, Brian ...
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Larsson, Henrik, ...
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Mataix-Cols, Dav ...
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visa färre...
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MEDICIN OCH HÄLS ...
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och Neurologi
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MEDICIN OCH HÄLS ...
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och Psykiatri
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Molecular Psychi ...
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Örebro universitet
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Karolinska Institutet